N-((2-Chlorophenyl)methyl)thiophene-2-ethylamine hydrochloride

Base Information

• Chemical Name: N-((2-Chlorophenyl)methyl)thiophene-2-ethylamine hydrochloride
• CAS No.: 60612-23-9
• Molecular Formula: C13H14 Cl N S . Cl H
• Molecular Weight: 288.241
• Hs Code.: 2934999090
• European Community (EC) Number: 262-327-7,273-851-0
• DSSTox Substance ID: DTXSID50209420
• Mol file: 60612-23-9.mol

Synonyms:60612-23-9;N-((2-Chlorophenyl)methyl)thiophene-2-ethylamine hydrochloride;N-[(2-chlorophenyl)methyl]-2-thiophen-2-ylethanamine;hydrochloride;EINECS 262-327-7;n-(2-chlorobenzyl)-2-(thiophen-2-yl)ethanamine hydrochloride;N-(2-CHLOROBENZYL)-2-(2-THIENYL)ETHYLAMINE HYDROCHLORIDE;N-(2-Chlorobenzyl)-2-(thiophen-2-yl)ethan-1-amine hydrochloride;N-[(2-chlorophenyl)methyl]thiophene-2-ethylamine hydrochloride;N-[(2-Chlorophenyl)methyl]thiophene-3-ethylamine;starbld0002310;C13H14ClNS.ClH;N-2-CHLOROBENZYLAMINE;SCHEMBL8088250;DTXSID50209420;C13-H14-Cl-N-S.Cl-H;QDHAJZRYUIMPDU-UHFFFAOYSA-N;BCP34244;FT-0629114;W-111383;N-(2-chloro-benzyl)-2-(2-thienyl)-ethylamine hydrochloride;N-(2-chloro-benzyl)-2-(2-thienyl)ethylamine hydrochloride;N-(2-chlorobenzyl )-2-(2-thienyl)-ethylamine hydrochloride;N-(2-chlorobenzyl)-2-(2-thienyl)-ethylamine hydrochloride;N-[(2-chlorophenyl-methyl)]-2-(2-thienyl)ethylamine HCl;2-Thiopheneethanamine,N-[(2-chlorophenyl)methyl]-,hydrochloride(1:1)

Chemical Property of N-((2-Chlorophenyl)methyl)thiophene-2-ethylamine hydrochloride

Chemical Property:

• Vapor Pressure: 2.3E-05mmHg at 25°C
• Melting Point: 143 °C
• Boiling Point: 359.9°C at 760 mmHg
• Flash Point: 171.5°C
• PSA: 40.27000
• LogP: 4.92670
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 287.0302260
• Heavy Atom Count: 17
• Complexity: 200

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)CNCCC2=CC=CS2)Cl.Cl
• Uses: N-(2-Chlorobenzyl)-2-(2-thienyl)ethylamine is an intermediate used to prepare acid addition salts of 4, 5, 6, 7 - tetrahydrothieno (3,2-c) pyridine derivatives having antithrombotic activity.

Technology Process of N-((2-Chlorophenyl)methyl)thiophene-2-ethylamine hydrochloride

There total 7 articles about N-((2-Chlorophenyl)methyl)thiophene-2-ethylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-(2-thienyl)-ethyl paratoluene sulfonate + ortho-chlorobenzylamine paratoluene sulfonate + 2-CHLOROBENZYLAMINE (89-97-4) → N-(2-chloro-benzyl)-2-(thien-2-yl)-ethylamine hydrochloride (60612-23-9)

Guidance literature:

With sodium hydroxide; In acetonitrile;

Reference yield: 55.0%

→ N-(2-chloro-benzyl)-2-(thien-2-yl)-ethylamine hydrochloride (60612-23-9)

Guidance literature:

Reference yield:

2-(2-thienyl)ethyl tosylate (40412-06-4) + 2-CHLOROBENZYLAMINE (89-97-4) → N-(2-chloro-benzyl)-2-(thien-2-yl)-ethylamine hydrochloride (60612-23-9)

Guidance literature:

2-(2-thienyl)ethyl tosylate; 2-CHLOROBENZYLAMINE; In toluene; at 85 ℃; for 3h;

With hydrogenchloride; In water; toluene; at 20 ℃; for 1h; pH=8.5; Temperature;

upstream raw materials:

2-thienyl lithium

N-(2-chlorobenzyl)-2,2-dioxo-1,2,3-oxathiazolidine

oxirane

p-toluenesulfonyl chloride

Downstream raw materials:

ticlopidine hydrochloride

Refernces

• 1、 -. "Method for synthesizing ticlopidine hydrochloride". . . Retrieved 2016/10/31.
• 2、 -. "Preparation method of ticlopidine hydrochloride". . . Retrieved 2017/03/25.