H-TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG-OH

Base Information

• Chemical Name: H-TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG-OH
• CAS No.: 191936-91-1
• Molecular Formula: C₆₄H₁₁₈N₃₂O₁₄
• Molecular Weight: 1559.85
• Mol file: 191936-91-1.mol

Synonyms:10: PN:JP2003009883 SEQID: 7 unclaimed; 10: PN: US20030008961 SEQID: 10 unclaimedsequence; 10: PN: US20090047703 SEQID: 10 unclaimed protein; 10: PN:US20100008891 SEQID: 10 unclaimed protein; 10: PN: WO0168854 SEQID: 8 unclaimedprotein; 10: PN: WO0170977 SEQID: 9 unclaimed protein; 10: PN: WO2009114614SEQID: 10 unclaimed protein; 10: PN: WO2009149562 SEQID: 9 claimed sequence;110: PN: JP2001157588 SEQID: 3 unclaimed protein; 115: PN: WO2004089396 PAGE:14 unclaimed sequence; 11: PN: US20020127647 SEQID: 13 unclaimed sequence; 11:PN: WO03106626 SEQID: 24 unclaimed sequence; 11: PN: WO2004096826 PAGE: 17claimed sequence; 11: PN: WO2009039188 PAGE: 19 unclaimed sequence; 126: PN:WO2009029678 SEQID: 125 unclaimed sequence; 127: PN: WO03068930 SEQID: 127unclaimed sequence; 12: PN: US20030190364 SEQID: 12 claimed sequence; 12: PN:US20070154437 SEQID: 11 claimed sequence; 12: PN: US20070191591 SEQID: 12claimed sequence; 12: PN: US7329729 SEQID: 12 unclaimed sequence; 12: PN:WO2005072159 SEQID: 12 unclaimed sequence; 12: PN: WO2010000675 SEQID: 10 unclaimedsequence; 138: PN: WO2007106799 SEQID: 236 unclaimed sequence; 13: PN:US20020037524 SEQID: 13 unclaimed protein; 13: PN: US20030124092 SEQID: 13unclaimed sequence; 13: PN: US20050208036 SEQID: 18 unclaimed sequence; 13: PN:WO0208285 SEQID: 13 unclaimed protein; 13: PN: WO03076623 SEQID: 13 unclaimedsequence; 13: PN: WO2007044468 SEQID: 19 unclaimed sequence; 14: PN:US20040043463 PAGE: 8 claimed protein; 14: PN: US6706685 SEQID: 14 claimedsequence; 14: PN: WO0200724 SEQID: 13 unclaimed protein; 14: PN: WO02097046SEQID: 14 unclaimed sequence; 14: PN: WO2005117538 SEQID: 2 unclaimed sequence;14: PN: WO2006116874 SEQID: 14 unclaimed sequence; 14: PN: WO2007069068 TABLE:1 unclaimed sequence; 14: PN: WO2008109686 SEQID: 14 unclaimed protein; 15: PN:JP2004201547 SEQID: 7 unclaimed sequence; 15: PN: JP2005287418 SEQID: 15unclaimed protein; 15: PN: US20030083261 SEQID: 20 unclaimed sequence;

Chemical Property of H-TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG-OH

Chemical Property:

• PSA: 841.08000
• Density: 1.54±0.1 g/cm3(Predicted)
• LogP: 3.78490
• Storage Temp.: ?20°C
• Solubility.: deionized water: soluble

Purity/Quality:

98%,99%, ^*data from raw suppliers

HIV-1 Tat Protein (47-57) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG-OH

There total 2 articles about H-TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) + Fmoc-Tyr(tBu)-OH (71989-38-3,118488-18-9,204384-67-8) + Fmoc-Lys(tert-butoxycarbonyl) (71989-26-9) + Fmoc-Arg(Pbf)-OH (119831-72-0,157774-30-6) → Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg (191936-91-1)

Guidance literature:

Multistep reaction;

DOI:10.1021/ol034977v

Reference yield:

N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) + Fmoc-Tyr(tBu)-OH (71989-38-3,118488-18-9,204384-67-8) + Fmoc-Lys(tert-butoxycarbonyl) (71989-26-9) + Fmoc-L-Gln(Trt)-OH (132327-80-1,200623-62-7) + Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine (187618-60-6) → Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg (191936-91-1)

Guidance literature:

Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;

With piperidine;

N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Tyr(tBu)-OH; Fmoc-Lys(tert-butoxycarbonyl); Fmoc-L-Gln(Trt)-OH; Further stages;

DOI:10.1021/acs.bioconjchem.7b00772

upstream raw materials:

N-(fluoren-9-ylmethoxycarbonyl)glycine

Fmoc-Tyr(tBu)-OH

Fmoc-Lys(tert-butoxycarbonyl)

Fmoc-Arg(Pbf)-OH

Refernces

• 1、 Bansal, Kavita,Aqdas, Mohammad,Kumar, Munish,Bala, Rajni,Singh, Sanpreet,Agrewala, Javed N.,Katare,Sharma, Rohit K.,Wangoo, Nishima. "A Facile Approach for Synthesis and Intracellular Delivery of Size Tunable Cationic Peptide Functionalized Gold Nanohybrids in Cancer Cells". . p. 1102 - 1110. Retrieved 2018.