D-PROLINE TERT-BUTYL ESTER HYDROCHLORIDE

Base Information

• Chemical Name: D-PROLINE TERT-BUTYL ESTER HYDROCHLORIDE
• CAS No.: 184719-80-0
• Molecular Formula: C₉H₁₇NO₂*ClH
• Molecular Weight: 207.7
• Hs Code.: 2933990090
• Mol file: 184719-80-0.mol

Synonyms:D-Proline,1,1-dimethylethyl ester, hydrochloride (9CI); (R)-Proline tert-butyl esterhydrochloride; D-Proline tert-butyl ester hydrochloride; D-Proline tert-butylester hydrochloride

Chemical Property of D-PROLINE TERT-BUTYL ESTER HYDROCHLORIDE

Chemical Property:

• Melting Point: 94 °C
• Refractive Index: 31 ° (C=1, H2O)
• PSA: 38.33000
• LogP: 2.21090
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: Soluble in water

Purity/Quality:

98%,99%, ^*data from raw suppliers

D-Proline tert-butyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of D-PROLINE TERT-BUTYL ESTER HYDROCHLORIDE

There total 4 articles about D-PROLINE TERT-BUTYL ESTER HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

isobutene (115-11-7,15220-85-6) + L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → L-proline tert-butyl ester hydrochloride (5497-76-7,184719-80-0,256478-96-3)

Guidance literature:

With sulfuric acid; In 1,4-dioxane;

DOI:10.1016/S0040-4020(01)91366-3

Reference yield:

N-BOC-proline tert-butyl ester (91237-84-2) → L-proline tert-butyl ester hydrochloride (5497-76-7,184719-80-0,256478-96-3)

Guidance literature:

With hydrogenchloride; In ethyl acetate; Yield given; Ambient temperature;

DOI:10.1021/jo00090a045

Reference yield:

proline tert-butyl ester (2812-46-6) → L-proline tert-butyl ester hydrochloride (5497-76-7,184719-80-0,256478-96-3)

Guidance literature:

Multi-step reaction with 2 steps

2: 1 M HCl / ethyl acetate / Ambient temperature

With hydrogenchloride; In ethyl acetate;

DOI:10.1021/jo00090a045

upstream raw materials:

N-BOC-proline tert-butyl ester

isobutene

L-proline

proline tert-butyl ester

Downstream raw materials:

(S)-tert-butyl 1-(2-(((benzyloxy)carbonyl)amino)acetyl)pyrrolidine-2-carboxylate

(S)-1-[2-(Trityl-amino)-acetyl]-pyrrolidine-2-carboxylic acid tert-butyl ester

Z-Phe-D-Val-Pro-OBu^t

Z-Phe-Val-Pro-OBu^t

Refernces

• 1、 Thorsen, M.,Andersen, T. P.,Pedersen, U.,Yde, B.,Lawesson, S.-O.,Hansen. H. F.. "STUDIES ON AMINO ACIDS AND PEPTIDES X. HPLC-MEDIATED TEST OF 2,4-BIS(4-METHOXYPHENYL)-1,3,2,4-DITHIADIPHOSPHETANE 2,4-DISULFIDE (LAWESSONS'S REAGENT) AS A RACEMIZATIONFREE COUPLING REAGENT IN PEPTIDE SYNTHESIS". . p. 5633 - 5636. Retrieved 2007/10/02.