octahydro-2-benzyl-5-(2-pyrimidinyl)pyrrolo<3,4-c>pyrrole

Base Information

• Chemical Name: octahydro-2-benzyl-5-(2-pyrimidinyl)pyrrolo<3,4-c>pyrrole
• CAS No.: 86732-39-0
• Molecular Formula: C₁₇H₂₀N₄
• Molecular Weight: 280.373
• Mol file: 86732-39-0.mol

Synonyms:octahydro-2-benzyl-5-(2-pyrimidinyl)pyrrolo<3,4-c>pyrrole

Chemical Property of octahydro-2-benzyl-5-(2-pyrimidinyl)pyrrolo<3,4-c>pyrrole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of octahydro-2-benzyl-5-(2-pyrimidinyl)pyrrolo<3,4-c>pyrrole

There total 6 articles about octahydro-2-benzyl-5-(2-pyrimidinyl)pyrrolo<3,4-c>pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-benzyloctahydropyrrolo[3,4-c]pyrrole (86732-22-1) + 2-bromopyrimidine (4595-60-2) → octahydro-2-benzyl-5-(2-pyrimidinyl)pyrrolo<3,4-c>pyrrole (86732-39-0)

Guidance literature:

With potassium carbonate; In toluene; Heating;

Reference yield:

1-benzyl-pyrrole-3,4-dicarboxylic acid (86731-90-0) → octahydro-2-benzyl-5-(2-pyrimidinyl)pyrrolo<3,4-c>pyrrole (86732-39-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 88 percent / dicyclohexylcarbodiimide / tetrahydrofuran / Heating; overnight

2: 84 percent / tetrahydrofuran / 60 °C / overnight

3: 90 percent / SOCl₂ / dimethylformamide / 0.75 h / 45 °C

4: H₂ / 10percent Pd/C / acetic acid / 18 h / 55 °C / 2585.7 Torr

5: 78 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 16 h / Heating

6: 80 percent / K₂CO₃ / toluene / Heating

With lithium aluminium tetrahydride; thionyl chloride; hydrogen; potassium carbonate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; acetic acid; N,N-dimethyl-formamide; toluene;

Reference yield:

1-benzyl-1H-pyrrole-3,4-dicarboxylic anhydride (86731-92-2) → octahydro-2-benzyl-5-(2-pyrimidinyl)pyrrolo<3,4-c>pyrrole (86732-39-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 84 percent / tetrahydrofuran / 60 °C / overnight

2: 90 percent / SOCl₂ / dimethylformamide / 0.75 h / 45 °C

3: H₂ / 10percent Pd/C / acetic acid / 18 h / 55 °C / 2585.7 Torr

4: 78 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 16 h / Heating

5: 80 percent / K₂CO₃ / toluene / Heating

With lithium aluminium tetrahydride; thionyl chloride; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; acetic acid; N,N-dimethyl-formamide; toluene;

upstream raw materials:

2-benzyloctahydropyrrolo[3,4-c]pyrrole

2-bromopyrimidine

1-benzyl-pyrrole-3,4-dicarboxylic acid

1-benzyl-1H-pyrrole-3,4-dicarboxylic anhydride

Refernces