N-(2,4-dimethylphenyl)-2,2,2-trifluoroethanimidoyl chloride

Base Information

• Chemical Name: N-(2,4-dimethylphenyl)-2,2,2-trifluoroethanimidoyl chloride
• CAS No.: 70314-82-8
• Molecular Formula: C₁₀H₉ClF₃N
• Molecular Weight: 235.636
• Mol file: 70314-82-8.mol

Synonyms:N-(2,4-dimethylphenyl)-2,2,2-trifluoroethanimidoyl chloride

Chemical Property of N-(2,4-dimethylphenyl)-2,2,2-trifluoroethanimidoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2,4-dimethylphenyl)-2,2,2-trifluoroethanimidoyl chloride

There total 2 articles about N-(2,4-dimethylphenyl)-2,2,2-trifluoroethanimidoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2,4-Xylidine (95-68-1) + trifluoroacetic acid (76-05-1) → N-(2,4-dimethylphenyl)-2,2,2-trifluoroethanimidoyl chloride (70314-82-8)

Guidance literature:

trifluoroacetic acid; With tetrachloromethane; triethylamine; triphenylphosphine; In 1,2-dichloro-ethane; at 0 ℃; for 0.166667h;

2,4-Xylidine; In 1,2-dichloro-ethane; Reflux;

DOI:10.1002/anie.201812525

Reference yield:

→ N-(2,4-dimethylphenyl)-2,2,2-trifluoroethanimidoyl chloride (70314-82-8)

Guidance literature:

/BRN= 214358/, BCl3;

DOI:10.1007/BF00903748

Reference yield: 99.0%

N-(2,4-dimethylphenyl)-2,2,2-trifluoroethanimidoyl chloride (70314-82-8) + 2-Mercapto-1-methylimidazole (60-56-0) → 1-(1-((2,4-dimethylphenyl)imino)-2,2,2-trifluoroethyl)-3-methyl-1H-imidazole-2(3H)-thione

Guidance literature:

2-Mercapto-1-methylimidazole; With sodium hydride; In acetonitrile; at 25 ℃; for 0.5h;

N-(2,4-dimethylphenyl)-2,2,2-trifluoroethanimidoyl chloride; In acetonitrile; at 25 ℃; for 9h;

DOI:10.1016/j.jfluchem.2016.08.010

upstream raw materials:

2,4-Xylidine

trifluoroacetic acid

Downstream raw materials:

C₂₇H₂₆F₄N₄O₃

1-(2,4-dimethylphenyl)-4-(4-methylbenzenesulfonyl)-5-(trifluoromethyl)-1H-imidazole

Refernces

• 1、 Rahmani, Fariba,Darehkordi, Ali. "Preparation of Trifluoromethylated (Arylaminomethylene)malononitriles Suitable for Synthesis of 4-Amino-2-(trifluoromethyl) quinoline Derivatives by Intramolecular Friedel-Crafts Reaction". . p. 2124 - 2130. Retrieved 2018/04/05.
• 2、 Ramezani, Mahin,Darehkordi, Ali. "Synthesis of new (trifluoromethyl)-1H-benzo[e][1,2,4]triazolo[1,2-a][1,2,4]triazine-1,3(2H)-diones and (trifluoromethyl)benzo[5,6][1,2,4]triazino [1,2-b]phthalazine-8,13-diones". . p. 89 - 97. Retrieved 2016/12/16.