2,6-Dibromo-4-nitropyridine

Base Information

• Chemical Name: 2,6-Dibromo-4-nitropyridine
• CAS No.: 175422-04-5
• Molecular Formula: C5H2Br2N2O2
• Molecular Weight: 281.891
• Hs Code.: 2933399090
• European Community (EC) Number: 675-760-5
• DSSTox Substance ID: DTXSID70581316
• Nikkaji Number: J819.691E
• Wikidata: Q72464702
• Mol file: 175422-04-5.mol

Synonyms:2,6-dibromo-4-nitropyridine;175422-04-5;2,6-Dibromo-4-nitro-pyridine;pyridine, 2,6-dibromo-4-nitro-;MFCD07369947;4-nitro-2,6-dibromopyridine;SCHEMBL220662;DTXSID70581316;XIPATZUHJFQGQC-UHFFFAOYSA-N;CS-B0696;AKOS015833739;PB41264;AC-30985;DS-11711;SY028728;A3895;AM20070083;EN300-316073;doi:10.14272/XIPATZUHJFQGQC-UHFFFAOYSA-N.1;W-206225

Chemical Property of 2,6-Dibromo-4-nitropyridine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.65
• Boiling Point: 330.018 °C at 760 mmHg
• PKA: -7.58±0.10(Predicted)
• Flash Point: 153.389 °C
• PSA: 58.71000
• Density: 2.222 g/cm³
• LogP: 3.03800
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 281.84625
• Heavy Atom Count: 11
• Complexity: 151

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,6-Dibromo-4-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=C(N=C1Br)Br)[N+](=O)[O-]
• Uses: 2,6-Dibromo-4-nitropyridine

Technology Process of 2,6-Dibromo-4-nitropyridine

There total 6 articles about 2,6-Dibromo-4-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,6-dibromo-4-nitro-pyridine 1-oxide (98027-81-7) → 2,6-dibromo-4-nitropyridine (175422-04-5)

Guidance literature:

With phosphorus tribromide; In acetonitrile; for 14h; Heating;

DOI:10.1021/jm021085c

Reference yield:

2,6-Dibromopyridine (626-05-1) → 2,6-dibromo-4-nitropyridine (175422-04-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / aq. H₂O₂; CF₃COOH / 3 h / 100 °C

2: 80 percent / HNO₃; H₂SO₄ / 1.5 h / 100 °C

3: 99 percent / PBr₃ / acetonitrile / 14 h / Heating

With sulfuric acid; dihydrogen peroxide; nitric acid; phosphorus tribromide; trifluoroacetic acid; In acetonitrile;

DOI:10.1021/jm021085c

Reference yield:

2,6-dibromopyridin N-oxide (25373-69-7) → 2,6-dibromo-4-nitropyridine (175422-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / HNO₃; H₂SO₄ / 1.5 h / 100 °C

2: 99 percent / PBr₃ / acetonitrile / 14 h / Heating

With sulfuric acid; nitric acid; phosphorus tribromide; In acetonitrile;

DOI:10.1021/jm021085c

upstream raw materials:

2,6-dibromo-4-nitro-pyridine 1-oxide

2,6-Dibromopyridine

2,6-dibromopyridin N-oxide

Downstream raw materials:

2,6-dibromo-4-(N-methyl-N-octylamino)pyridine

(2,6-dibromo-pyridin-4-yl)-(2-pyridin-2-yl-ethyl)-amine

(2,6-dibromo-pyridin-4-yl)-(3-fluoro-biphenyl-2-yl)-amine

4-(2,6-dibromopyridine-4-sulphonyl)-phenylamine

Refernces

• 1、 Hirao, Yasukazu,Teraoka, Mitsuru,Kubo, Takashi. "Interaction of the dihydropyridine/pyridinium redox pair fixed into a V-shaped conformation". . p. 1345 - 1353. Retrieved 2019/12/23.
• 2、 -. "MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES". . . Retrieved 2012/05/04.