1-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazole-5-ylcarboxylic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide acetate salt

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Chemical Name:1-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazole-5-ylcarboxylic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide acetate salt
CAS No.:1188417-09-5
Molecular Formula:C₂H₄O₂*C₂₇H₂₆N₆O₃
Molecular Weight:542.594
Hs Code.:
Mol file:1188417-09-5.mol

Synonyms:1-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazole-5-ylcarboxylic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide acetate salt

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Chemical Property of 1-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazole-5-ylcarboxylic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide acetate salt Edit

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Technology Process of 1-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazole-5-ylcarboxylic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide acetate salt

There total 4 articles about 1-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazole-5-ylcarboxylic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide acetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 42288-26-6
(4-cyanophenyl)glycine

: 64-19-7,77671-22-8
acetic acid

: 212322-56-0
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate

: 1188417-09-5
1-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazole-5-ylcarboxylic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide acetate salt

Guidance literature:: (4-cyanophenyl)glycine; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; for 0.666667h; Inert atmosphere; Reflux;

ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate; In tetrahydrofuran; for 5h; Inert atmosphere; Reflux;

acetic acid; In tetrahydrofuran; for 1h; Reflux;

Reference yield:

: 3-amino-4-[N-[2-(4-cyanophenylamino)acetyl]-N-methylamino]benzoic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide

: 64-19-7,77671-22-8
acetic acid

: 1188417-09-5
1-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazole-5-ylcarboxylic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide acetate salt

Guidance literature:: 3-amino-4-[N-[2-(4-cyanophenylamino)acetyl]-N-methylamino]benzoic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide; In toluene; Dean-Stark; Reflux;

acetic acid; In toluene; for 0.5h; Reflux;

Reference yield:

: 42288-26-6
(4-cyanophenyl)glycine

: 1188417-09-5
1-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazole-5-ylcarboxylic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide acetate salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / Reflux

2.1: dichloromethane / 4 h / Reflux

3.1: toluene / Dean-Stark; Reflux

3.2: 0.5 h / Reflux

In dichloromethane; toluene;