(2-amino-5-fluorophenyl)phosphonate de diethyle

Base Information

• Chemical Name: (2-amino-5-fluorophenyl)phosphonate de diethyle
• CAS No.: 166818-87-7
• Molecular Formula: C₁₀H₁₅FNO₃P
• Molecular Weight: 247.206
• Mol file: 166818-87-7.mol

Synonyms:(2-amino-5-fluorophenyl)phosphonate de diethyle

Chemical Property of (2-amino-5-fluorophenyl)phosphonate de diethyle

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-amino-5-fluorophenyl)phosphonate de diethyle

There total 5 articles about (2-amino-5-fluorophenyl)phosphonate de diethyle which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-fluoro-2-iodoaniline (61272-76-2) + phosphonic acid diethyl ester (762-04-9) → (2-amino-5-fluorophenyl)phosphonate de diethyle (166818-87-7)

Guidance literature:

With potassium tert-butylate; In ammonia; at -33 ℃; for 1.5h; Irradiation;

Reference yield:

2-bromo-4-fluoroaniline (1003-98-1) + phosphonic acid diethyl ester (762-04-9) → (2-amino-5-fluorophenyl)phosphonate de diethyle (166818-87-7) + 4-fluoroaniline (371-40-4)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Further Variations:; Solvents; time; Product distribution; Irradiation;

DOI:10.1055/s-1999-3553

Reference yield:

4-bromo-2-fluoroaniline (367-24-8) + phosphonic acid diethyl ester (762-04-9) → 2-Fluoroaniline (348-54-9) + diethyl (4-aminophenyl)phosphonate (42822-57-1) + (2-amino-5-fluorophenyl)phosphonate de diethyle (166818-87-7)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 3.25h; Further Variations:; Solvents; time; Product distribution; Irradiation;

DOI:10.1055/s-1999-3553

upstream raw materials:

4-fluoro-2-iodoaniline

phosphonic acid diethyl ester

4-bromo-2-fluoroaniline

2-bromo-4-fluoroaniline

Refernces

• 1、 Defacqz, Nathalie,De Bueger, Bruno,Touillaux, Roland,Cordi, Alex,Marchand-Brynaert, Jacqueline. "Direct phosphonylation of mono- and dihalogenoanilines". . p. 1368 - 1372. Retrieved 2007/10/03.