QUINOLINE-3-SULFONYL CHLORIDE

Base Information

• Chemical Name: QUINOLINE-3-SULFONYL CHLORIDE
• CAS No.: 159182-40-8
• Molecular Formula: C9H6 Cl N O2 S
• Molecular Weight: 227.671
• Mol file: 159182-40-8.mol

Synonyms:QUINOLINE-3-SULFONYL CHLORIDE

Chemical Property of QUINOLINE-3-SULFONYL CHLORIDE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: NA
• Refractive Index: 1.647
• Boiling Point: 385.826°C at 760 mmHg
• PKA: 0.31±0.12(Predicted)
• Flash Point: 187.141°C
• PSA: 55.41000
• Density: 1.484g/cm³
• LogP: 3.24310
• Storage Temp.: Hygroscopic, Store under Inert atmosphere -20°C Freezer

Purity/Quality:

98% ^*data from raw suppliers

Quinoline-3-sulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of QUINOLINE-3-SULFONYL CHLORIDE

There total 5 articles about QUINOLINE-3-SULFONYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

3-mercaptoquinoline (76076-35-2) → quinoline-3-sulfonyl chloride (159182-40-8)

Guidance literature:

With hydrogenchloride; chlorine; at -10 - -8 ℃; for 0.5h;

DOI:10.3987/COM-07-11088

Reference yield: 84.0%

3-(benzylthio)quinoline (1207164-22-4) → quinoline-3-sulfonyl chloride (159182-40-8)

Guidance literature:

With 1,3-dichloro-5,5-dimethylhydantoin; acetic acid; In dichloromethane; water; at 0 - 5 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2009.11.047

Reference yield: 29.0%

3-bromoquinoline (5332-24-1) → quinoline-3-sulfonyl chloride (159182-40-8)

Guidance literature:

3-bromoquinoline; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.666667h;

With sulfur dioxide; In tetrahydrofuran; at -78 - 20 ℃; for 1h;

With N-chloro-succinimide; In dichloromethane; at 0 - 20 ℃; for 0.5h;

upstream raw materials:

3-bromoquinoline

3-mercaptoquinoline

3-(benzylthio)quinoline

3,3'-bisquinolinyl disulfide

Downstream raw materials:

C₂₇H₂₄FN₃O₅S₂

N-(2,5-dimethoxyphenyl)quinoline-3-sulfonamide

N-ethyl-N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-3-quinolinesulfonamide

N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)quinoline-3-sulfonamide

Refernces

• 1、 Marciniec, Krzysztof,Ma?lankiewicz, Andrzej,Ma?lankiewicz, Maria J.,Kurczab, Rafa?. "Synthesis, 15N NMR spectra and GIAO calculated data of the seven positional isomers of 15N-labeled N,N-dimethylsulfamoylquinoline". experimental part. p. 46 - 50. Retrieved 2012/06/04.
• 2、 Pu, Yu-Ming,Christesen, Alan,Ku, Yi-Yin. "A simple and highly effective oxidative chlorination protocol for the preparation of arenesulfonyl chlorides". supporting information; experimental part. p. 418 - 421. Retrieved 2010/03/04.