Technology Process of N-((3-hydroxy-4-methylphenyl)methyl)-4-amino-1-methylpiperidine
There total 10 articles about N-((3-hydroxy-4-methylphenyl)methyl)-4-amino-1-methylpiperidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium cyanoborohydride; acetic acid;
In
methanol;
at 0 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium cyanoborohydride; acetic acid / methanol / 20 h / pH ~ 5
1.2: pH ~ 10
2.1: triethylamine / dichloromethane / 0.17 h / 0 °C
2.2: 1.25 h / 0 °C
3.1: potassium carbonate / methanol / 24 h / 40 °C
4.1: formic acid / palladium 10% on activated carbon / methanol / 24 h / Heating / reflux
5.1: sodium cyanoborohydride; acetic acid / methanol / 3 h / 0 °C
With
formic acid; sodium cyanoborohydride; potassium carbonate; acetic acid; triethylamine;
palladium 10% on activated carbon;
In
methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane / 0.17 h / 0 °C
1.2: 1.25 h / 0 °C
2.1: potassium carbonate / methanol / 24 h / 40 °C
3.1: formic acid / palladium 10% on activated carbon / methanol / 24 h / Heating / reflux
4.1: sodium cyanoborohydride; acetic acid / methanol / 3 h / 0 °C
With
formic acid; sodium cyanoborohydride; potassium carbonate; acetic acid; triethylamine;
palladium 10% on activated carbon;
In
methanol; dichloromethane;