4-Bromo-benzenesulfonic acid (1R,3S)-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl ester

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Chemical Name:4-Bromo-benzenesulfonic acid (1R,3S)-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl ester
CAS No.:387353-75-5
Molecular Formula:C₃₁H₄₃BrO₈S
Molecular Weight:655.648
Hs Code.:
Mol file:387353-75-5.mol

4-Bromo-benzenesulfonic acid (1R,3S)-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl ester

Synonyms:4-Bromo-benzenesulfonic acid (1R,3S)-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl ester

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Chemical Property of 4-Bromo-benzenesulfonic acid (1R,3S)-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl ester Edit

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Technology Process of 4-Bromo-benzenesulfonic acid (1R,3S)-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl ester

There total 14 articles about 4-Bromo-benzenesulfonic acid (1R,3S)-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 172900-75-3
4-methoxy-3-(3-methoxypropoxy)benzaldehyde

: 387353-75-5
4-Bromo-benzenesulfonic acid (1R,3S)-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: 82 percent

2.1: H₂ / Pd/C / ethyl acetate / 20 °C

3.1: (COCl)2 / dimethylformamide / 20 °C

4.1: NaOH / toluene / 20 °C

5.1: LDA; LiCl / tetrahydrofuran / 0 °C

5.2: tetrahydrofuran / 20 °C / Heating

6.1: 66 percent / BH₃*NH₃; n-BuLi / tetrahydrofuran / 20 °C

7.1: POCl₃; DMF / toluene / 80 °C

8.1: 51 percent

9.1: DMAP / CH₂Cl₂ / 20 °C

With dmap; sodium hydroxide; n-butyllithium; borane-ammonia complex; oxalyl dichloride; hydrogen; N,N-dimethyl-formamide; lithium chloride; lithium diisopropyl amide; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; 1.1: Knoevenagel condensation;
DOI:10.1016/S0040-4039(00)01760-3

Reference yield:

: 324763-36-2
(E)-3-[4-Methoxy-3-(3-methoxy-propoxy)-phenyl]-acrylic acid

: 387353-75-5
4-Bromo-benzenesulfonic acid (1R,3S)-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: H₂ / Pd/C / ethyl acetate / 20 °C

2.1: (COCl)2 / dimethylformamide / 20 °C

3.1: NaOH / toluene / 20 °C

4.1: LDA; LiCl / tetrahydrofuran / 0 °C

4.2: tetrahydrofuran / 20 °C / Heating

5.1: 66 percent / BH₃*NH₃; n-BuLi / tetrahydrofuran / 20 °C

6.1: POCl₃; DMF / toluene / 80 °C

7.1: 51 percent

8.1: DMAP / CH₂Cl₂ / 20 °C

With dmap; sodium hydroxide; n-butyllithium; borane-ammonia complex; oxalyl dichloride; hydrogen; N,N-dimethyl-formamide; lithium chloride; lithium diisopropyl amide; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(00)01760-3