(2S)-piperidine-1,2-dicarboxylic acid 1-tert-butyl 2-(3'-phenoxybenzyl) diester

Base Information

• Chemical Name: (2S)-piperidine-1,2-dicarboxylic acid 1-tert-butyl 2-(3'-phenoxybenzyl) diester
• CAS No.: 175721-89-8
• Molecular Formula: C₂₄H₂₉NO₅
• Molecular Weight: 411.498
• Mol file: 175721-89-8.mol

Synonyms:(2S)-piperidine-1,2-dicarboxylic acid 1-tert-butyl 2-(3'-phenoxybenzyl) diester

Chemical Property of (2S)-piperidine-1,2-dicarboxylic acid 1-tert-butyl 2-(3'-phenoxybenzyl) diester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-piperidine-1,2-dicarboxylic acid 1-tert-butyl 2-(3'-phenoxybenzyl) diester

There total 1 articles about (2S)-piperidine-1,2-dicarboxylic acid 1-tert-butyl 2-(3'-phenoxybenzyl) diester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Phenoxybenzyl alcohol (13826-35-2) + (S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid (26250-84-0) → (2S)-piperidine-1,2-dicarboxylic acid 1-tert-butyl 2-(3'-phenoxybenzyl) diester (175721-89-8)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 23 ℃; for 3h;

DOI:10.1021/jm950798a

Reference yield:

(2S)-piperidine-1,2-dicarboxylic acid 1-tert-butyl 2-(3'-phenoxybenzyl) diester (175721-89-8) → (S)-Piperidine-2-carboxylic acid 3-phenoxy-benzyl ester (1026482-73-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 23 ℃; for 2h;

DOI:10.1021/jm950798a

Reference yield:

(2S)-piperidine-1,2-dicarboxylic acid 1-tert-butyl 2-(3'-phenoxybenzyl) diester (175721-89-8) → (S)-1-(2,2-Dimethyl-propylcarbamoyl)-piperidine-2-carboxylic acid 3-phenoxy-benzyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / dioxane / 2 h / 23 °C

2: Et₃N / CH₂Cl₂ / 1 h / 23 °C

With hydrogenchloride; triethylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1021/jm950798a

upstream raw materials:

3-Phenoxybenzyl alcohol

(S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid

Downstream raw materials:

(S)-Piperidine-2-carboxylic acid 3-phenoxy-benzyl ester

Refernces