Technology Process of Boc-(τ-N-methyl)His amide of (3S,4S)-1-<<(3-methylbutyl)carbonyl>amino>-3-hydroxy-4-amino-5-cyclohexylpentane
There total 7 articles about Boc-(τ-N-methyl)His amide of (3S,4S)-1-<<(3-methylbutyl)carbonyl>amino>-3-hydroxy-4-amino-5-cyclohexylpentane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 10 min, 2.) THF, -78 deg C, 15 min
2: 95 percent / H2, NH3 / Raney Ni / methanol / 2280 Torr
3: 91 percent / Et3N / CH2Cl2 / 1 h / 0 °C
4: 4 M aq. HCl / dioxane
5: N-methylmorpholine, 1-hydroxybenzotriazole monohydrate, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 14 h / -23 - 20 °C
With
4-methyl-morpholine; hydrogenchloride; ammonia; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium diisopropyl amide;
nickel;
In
1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00390a018
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 65 percent / methanol; H2O / 18 h / Ambient temperature
2: 95 percent / H2, NH3 / Raney Ni / methanol / 2280 Torr
3: 91 percent / Et3N / CH2Cl2 / 1 h / 0 °C
4: 4 M aq. HCl / dioxane
5: N-methylmorpholine, 1-hydroxybenzotriazole monohydrate, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 14 h / -23 - 20 °C
With
4-methyl-morpholine; hydrogenchloride; ammonia; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
nickel;
In
1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00390a018
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 95 percent / H2, NH3 / Raney Ni / methanol / 2280 Torr
2: 91 percent / Et3N / CH2Cl2 / 1 h / 0 °C
3: 4 M aq. HCl / dioxane
4: N-methylmorpholine, 1-hydroxybenzotriazole monohydrate, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 14 h / -23 - 20 °C
With
4-methyl-morpholine; hydrogenchloride; ammonia; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
nickel;
In
1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00390a018
