pentafluorophenyl L-α-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-α-benzeneethanoate

Base Information

• Chemical Name: pentafluorophenyl L-α-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-α-benzeneethanoate
• CAS No.: 839719-68-5
• Molecular Formula: C₂₉H₁₈F₅NO₄
• Molecular Weight: 539.458
• Mol file: 839719-68-5.mol

Synonyms:pentafluorophenyl L-α-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-α-benzeneethanoate

Chemical Property of pentafluorophenyl L-α-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-α-benzeneethanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of pentafluorophenyl L-α-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-α-benzeneethanoate

There total 1 articles about pentafluorophenyl L-α-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-α-benzeneethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

pentafluorophenyl trifloroacetate (14533-84-7) + Fmoc-Phg-OH (102410-65-1,163883-97-4) → pentafluorophenyl L-α-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-α-benzeneethanoate (839719-68-5)

Guidance literature:

With pyridine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1021/jm049906w

Reference yield: 79.0%

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) + pentafluorophenyl L-α-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-α-benzeneethanoate (839719-68-5) → methyl 2-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-phenylacetamido)-3-phenylpropanoate (111524-86-8)

Guidance literature:

With 4-methyl-morpholine; In N,N-dimethyl-formamide; for 0.0125h; microwave irradiation;

Reference yield:

Fmoc-Tyr(tBu)-OPfp (86060-93-7) + Nα-Fmoc-L-Asn-OPfp (797751-68-9) + pentafluorophenyl L-α-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-α-benzeneethanoate (839719-68-5) → YFDD

Guidance literature:

N^α-Fmoc-L-Asn-OPfp; With pyrazolone orange; C₁₄H₁₂FeO₆^(1-)*Na⁽¹⁺⁾; In N,N-dimethyl-formamide; at 90 ℃; for 1h; Combinatorial reaction / High throughput screening (HTS); Inert atmosphere; solid phase reaction;

With piperidine; In N,N-dimethyl-formamide;

Fmoc-Tyr(tBu)-OPfp; N^α-Fmoc-L-Asn-OPfp; pentafluorophenyl L-α-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-α-benzeneethanoate; Further stages;

DOI:10.1002/anie.200801616

upstream raw materials:

pentafluorophenyl trifloroacetate

Fmoc-Phg-OH

Downstream raw materials:

methyl 2-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-phenylacetamido)-3-phenylpropanoate

(4-{[3-(2-amino-2-phenyl-acetylamino)-propyl]-tert-butoxycarbonyl-amino}-butyl)-(3-tert-butoxycarbonylamino-propyl)-carbamic acid tert-butyl ester

(3-tert-butoxycarbonylamino-propyl)-(4-{tert-butoxycarbonyl-[3-(2-butyrylamino-2-phenyl-acetylamino)-propyl]-amino}-butyl)-carbamic acid tert-butyl ester

Refernces