Cyclohexanecarboxylic acid bicyclo[4.2.0]octa-1,3,5-trien-7-ylmethyl-[(methoxymethyl-carbamoyl)-methyl]-amide

Base Information

• Chemical Name: Cyclohexanecarboxylic acid bicyclo[4.2.0]octa-1,3,5-trien-7-ylmethyl-[(methoxymethyl-carbamoyl)-methyl]-amide
• CAS No.: 93255-08-4
• Molecular Formula: C₂₀H₂₈N₂O₃
• Molecular Weight: 344.454
• Mol file: 93255-08-4.mol

Synonyms:Cyclohexanecarboxylic acid bicyclo[4.2.0]octa-1,3,5-trien-7-ylmethyl-[(methoxymethyl-carbamoyl)-methyl]-amide

Chemical Property of Cyclohexanecarboxylic acid bicyclo[4.2.0]octa-1,3,5-trien-7-ylmethyl-[(methoxymethyl-carbamoyl)-methyl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclohexanecarboxylic acid bicyclo[4.2.0]octa-1,3,5-trien-7-ylmethyl-[(methoxymethyl-carbamoyl)-methyl]-amide

There total 4 articles about Cyclohexanecarboxylic acid bicyclo[4.2.0]octa-1,3,5-trien-7-ylmethyl-[(methoxymethyl-carbamoyl)-methyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + Acetic acid [2-(bicyclo[4.2.0]octa-1,3,5-trien-7-ylmethyl-cyclohexanecarbonyl-amino)-acetylamino]-methyl ester (93255-07-3) → Cyclohexanecarboxylic acid bicyclo[4.2.0]octa-1,3,5-trien-7-ylmethyl-[(methoxymethyl-carbamoyl)-methyl]-amide (93255-08-4)

Guidance literature:

With potassium carbonate; for 16h; Ambient temperature;

DOI:10.1021/jo00200a057

Reference yield:

1-cyanobenzocyclobutane (6809-91-2) → Cyclohexanecarboxylic acid bicyclo[4.2.0]octa-1,3,5-trien-7-ylmethyl-[(methoxymethyl-carbamoyl)-methyl]-amide (93255-08-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 1. Na₂CO₃, 2. H₂ / 2.Raney-Ni / 1. a. water, RT, 1h, b. ethanol; 2. 20-25psi, 4 - 6h

2: 67 percent / Dicyclohexylcarbodiimide / CH₂Cl₂ / 24 h / Ambient temperature

3: 93 percent / acetic acid / 16 h / 75 - 80 °C

4: 99 percent / K₂CO₃ anhydrous / 16 h / Ambient temperature

With hydrogen; sodium carbonate; potassium carbonate; dicyclohexyl-carbodiimide; 2.Raney-Ni; In dichloromethane; acetic acid;

DOI:10.1021/jo00200a057

Reference yield:

Cyclohexanecarboxylic acid bicyclo[4.2.0]octa-1,3,5-trien-7-ylmethyl-carbamoylmethyl-amide (93255-06-2) → Cyclohexanecarboxylic acid bicyclo[4.2.0]octa-1,3,5-trien-7-ylmethyl-[(methoxymethyl-carbamoyl)-methyl]-amide (93255-08-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / acetic acid / 16 h / 75 - 80 °C

2: 99 percent / K₂CO₃ anhydrous / 16 h / Ambient temperature

With potassium carbonate; In acetic acid;

DOI:10.1021/jo00200a057

upstream raw materials:

methanol

Acetic acid [2-(bicyclo[4.2.0]octa-1,3,5-trien-7-ylmethyl-cyclohexanecarbonyl-amino)-acetylamino]-methyl ester

1-cyanobenzocyclobutane

Cyclohexanecarboxylic acid bicyclo[4.2.0]octa-1,3,5-trien-7-ylmethyl-carbamoylmethyl-amide

Downstream raw materials:

2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one

Refernces