5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide methanesulfonic acid salt

Base Information

• Chemical Name: 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide methanesulfonic acid salt
• CAS No.: 635702-65-7
• Molecular Formula: CH₄O₃S*C₂₁H₂₃N₇O₂S
• Molecular Weight: 533.632
• Mol file: 635702-65-7.mol

Synonyms:5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide methanesulfonic acid salt

Chemical Property of 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide methanesulfonic acid salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide methanesulfonic acid salt

There total 8 articles about 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide methanesulfonic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

pazopanib hydrochloride (635702-64-6) + methanesulfonic acid (75-75-2,98527-29-8) → 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide methanesulfonic acid salt (635702-65-7)

Guidance literature:

In water; for 0.0833333h; Heating / reflux;

Reference yield:

3-methyl-6-nitro-1H-indazole (6494-19-5) → 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide methanesulfonic acid salt (635702-65-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sulfuric acid / dimethyl sulfoxide / 72 h / 50 °C

2.1: palladium 10% on activated carbon / methanol; water / 6 h / 25 - 30 °C

3.1: sodium hydrogencarbonate / tetrahydrofuran; ethanol / 4 - 7 h / 74 - 85 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 20 - 30 °C

5.1: methanol / 3 h / 20 °C / Heating / reflux

5.2: 4 h

6.1: water / 0.08 h / Heating / reflux

With sulfuric acid; sodium hydrogencarbonate; caesium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

3-methyl-6-nitro-1H-indazole sulfate (635702-59-9) → 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide methanesulfonic acid salt (635702-65-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: dichloromethane; dimethyl sulfoxide / 25 - 70 °C / Heating / reflux

2.1: palladium 10% on activated carbon / methanol; water / 6 h / 25 - 30 °C

3.1: sodium hydrogencarbonate / tetrahydrofuran; ethanol / 4 - 7 h / 74 - 85 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 20 - 30 °C

5.1: methanol / 3 h / 20 °C / Heating / reflux

5.2: 4 h

6.1: water / 0.08 h / Heating / reflux

With sodium hydrogencarbonate; caesium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

upstream raw materials:

pazopanib hydrochloride

methanesulfonic acid

3-methyl-6-nitro-1H-indazole

2,3?dimethyl?6?nitro?2H?indazole

Refernces

• 1、 -. "CHEMICAL PROCESS". Page 54. . Retrieved 2010/02/04.