2,5,7-Trihydroxy-4'-methoxyflavanon

Base Information

• Chemical Name: 2,5,7-Trihydroxy-4'-methoxyflavanon
• CAS No.: 58124-20-2
• Molecular Formula: C₁₆H₁₄O₆
• Molecular Weight: 302.284
• Mol file: 58124-20-2.mol

Synonyms:2,5,7-Trihydroxy-4'-methoxyflavanon

Chemical Property of 2,5,7-Trihydroxy-4'-methoxyflavanon

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5,7-Trihydroxy-4'-methoxyflavanon

There total 3 articles about 2,5,7-Trihydroxy-4'-methoxyflavanon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[2,4-bis(benzyloxy)-6-hydroxyphenyl]ethanone (18065-05-9) → 2,5,7-Trihydroxy-4'-methoxyflavanon (58124-20-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / Reflux

2: potassium hydroxide / pyridine / 1 h / 85 °C / Inert atmosphere

3: hydrogen; palladium 10% on activated carbon / methanol; tetrahydrofuran

With dmap; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In tetrahydrofuran; pyridine; methanol; dichloromethane; 2: |Baker-Venkataraman Rearrangement;

DOI:10.1016/j.phytochem.2016.02.013

Reference yield:

2-acetyl-3,5-bis(benzyloxy)phenyl 4-methoxybenzoate → 2,5,7-Trihydroxy-4'-methoxyflavanon (58124-20-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / pyridine / 1 h / 85 °C / Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / methanol; tetrahydrofuran

With palladium 10% on activated carbon; hydrogen; potassium hydroxide; In tetrahydrofuran; pyridine; methanol; 1: |Baker-Venkataraman Rearrangement;

DOI:10.1016/j.phytochem.2016.02.013

Reference yield:

→ 2,5,7-Trihydroxy-4'-methoxyflavanon (58124-20-2)

Guidance literature:

Acacetin (6i), KOH, Δ;

upstream raw materials:

1-[2,4-bis(benzyloxy)-6-hydroxyphenyl]ethanone

Downstream raw materials:

4'-methoxy-5,7-dihydroxyflavone 6-D-glucopyranoside

apigenin 4'-methoxy-8-C-β-D-glucopyranoside

Refernces