(E)-1-(4-chlorophenyl)ethanone O-benzyl oxime

Base Information

• Chemical Name: (E)-1-(4-chlorophenyl)ethanone O-benzyl oxime
• CAS No.: 937371-83-0
• Molecular Formula: C₁₅H₁₄ClNO
• Molecular Weight: 259.735
• Mol file: 937371-83-0.mol

Synonyms:(E)-1-(4-chlorophenyl)ethanone O-benzyl oxime

Chemical Property of (E)-1-(4-chlorophenyl)ethanone O-benzyl oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-(4-chlorophenyl)ethanone O-benzyl oxime

There total 4 articles about (E)-1-(4-chlorophenyl)ethanone O-benzyl oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(E)-1-(4-chlorophenyl)ethanone oxime (1956-39-4) + benzyl chloride (100-44-7) → (E)-1-(4-chlorophenyl)ethanone O-benzyl oxime (937371-83-0)

Guidance literature:

(E)-1-(4-chlorophenyl)ethanone oxime; With sodium hydride; In N,N-dimethyl-formamide; for 24h; Cooling with ice;

benzyl chloride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.tetasy.2012.05.008

Reference yield:

(E)-1-(4-chlorophenyl)ethanone oxime (1956-39-4) → (E)-1-(4-chlorophenyl)ethanone O-benzyl oxime (937371-83-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/ol0704791

Reference yield:

para-chloroacetophenone (99-91-2) → (E)-1-(4-chlorophenyl)ethanone O-benzyl oxime (937371-83-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 5 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 24 h / Cooling with ice

2.2: 20 °C

With hydroxylamine hydrochloride; sodium acetate; sodium hydride; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.tetasy.2012.05.008

upstream raw materials:

(E)-1-(4-chlorophenyl)ethanone oxime

benzyl chloride

para-chloroacetophenone

Downstream raw materials:

(R)-N-[1-(4-chlorophenyl)ethyl]acetamide

(S)-N-[1-(4-chlorophenyl)ethyl]acetamide

(R)-1-(4-chlorophenyl)ethylamine

Refernces

• 1、 -. "CATALYTIC ASYMMETRIC SYNTHESIS OF PRIMARY AMINES VIA BORANE REDUCTION OF OXIME ETHERS USING SPIROBORATE ESTERS". Page/Page column 18-20. . Retrieved 2008/06/13.