(N-Succinimidyloxycarbonyl-methyl)tris(2,4,6-trimethoxyphenyl)phosphonium Bromide

Base Information

• Chemical Name: (N-Succinimidyloxycarbonyl-methyl)tris(2,4,6-trimethoxyphenyl)phosphonium Bromide
• CAS No.: 226409-58-1
• Molecular Formula: Br*C₃₃H₃₉NO₁₃P
• Molecular Weight: 768.549
• Hs Code.: 29251900
• DSSTox Substance ID: DTXSID00583500
• Mol file: 226409-58-1.mol

Synonyms:N-succinimidyloxycarbonylmethyl tris(2,4,6-trimethoxyphenyl)phosphonium;N-succinimidyloxycarbonylmethyl tris(2,4,6-trimethoxyphenyl)phosphonium bromide;TMPP-Ac-OSu

Chemical Property of (N-Succinimidyloxycarbonyl-methyl)tris(2,4,6-trimethoxyphenyl)phosphonium Bromide

Chemical Property:

• Melting Point: 201-205 °C (dec.)
• PSA: 160.34000
• LogP: -0.39300
• Storage Temp.: −20°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 16
• Exact Mass: 767.13424
• Heavy Atom Count: 49
• Complexity: 936

Purity/Quality:

97% ^*data from raw suppliers

(N-Succinimidyloxycarbonylmethyl)tris(2,4,6-trimethoxyphenyl)phosphonium bromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC(=C(C(=C1)OC)[P+](CC(=O)ON2C(=O)CCC2=O)(C3=C(C=C(C=C3OC)OC)OC)C4=C(C=C(C=C4OC)OC)OC)OC.[Br-]
• Uses: A reagent for modifying N-terminal of peptides for fast atom bombardment, FAB or matrix assisted laser desorption/ionization MS, MALDI MS. Used in protein sequencing (by MALDIMS). As a reagent for modifying N-terminal of peptides for fast atom bombardment, FAB or matrix assisted laser desorption/ionization MS, MALDI MS, (N-Succinimidyloxycarbonylmethyl)tris(2,4,6-trimethoxyphenyl)phosphonium bromide can be used in protein sequencing (by MALDIMS)

Technology Process of (N-Succinimidyloxycarbonyl-methyl)tris(2,4,6-trimethoxyphenyl)phosphonium Bromide

There total 1 articles about (N-Succinimidyloxycarbonyl-methyl)tris(2,4,6-trimethoxyphenyl)phosphonium Bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tris(2,4,6-trimethoxyphenyl)phosphine (91608-15-0) + bromoacetic acid N-hydroxusuccinimidyl ester (42014-51-7,133481-33-1,89803-01-0) → (N-succinimidyloxycarbonylmethyl) tris(2,4,6-trimethoxyphenyl)phosphonium bromide (226409-58-1)

Guidance literature:

In toluene; for 0.5h;

DOI:10.1021/ac035537k DOI:10.1021/ac061670b

Reference yield:

enoxacine + (N-succinimidyloxycarbonylmethyl) tris(2,4,6-trimethoxyphenyl)phosphonium bromide (226409-58-1) → [4-(6-carboxy-8-ethyl-3-fluoro-5-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-piperazin-1-yloxycarbonylmethyl]-tris-(2,4,6-trimethoxy-phenyl)-phosphonium; bromide

Guidance literature:

With triethanolamine; In water; acetonitrile; at 20 ℃; for 0.166667h; pH=9.9;

DOI:10.1021/ac035537k

upstream raw materials:

tris(2,4,6-trimethoxyphenyl)phosphine

bromoacetic acid N-hydroxusuccinimidyl ester

Refernces

• 1、 Chen, Weibin,Lee, Peter J.,Shion, Henry,Ellor, Nicholas,Gebler, John C.. "Improving de novo sequencing of peptides using a charged tag and C-terminal digestion". . p. 1583 - 1590. Retrieved 2007.