2-Chloro-2-fluoroacetyl fluoride

Base Information

• Chemical Name: 2-Chloro-2-fluoroacetyl fluoride
• CAS No.: 359-34-2
• Molecular Formula: C2H Cl F2 O
• Molecular Weight: 114.479
• Hs Code.: 2915900090
• DSSTox Substance ID: DTXSID00541221
• Nikkaji Number: J1.092.187B
• Mol file: 359-34-2.mol

Synonyms:2-chloro-2-fluoroacetyl fluoride;359-34-2;Chlorofluoroacetyl fluoride;Chloro(fluoro)acetyl fluoride;CHLOROFLUOROACETYLFLUORIDE;DTXSID00541221;2-chloro-2-fluoro-acetyl fluoride;AKOS025310378;A823050

Chemical Property of 2-Chloro-2-fluoroacetyl fluoride

Chemical Property:

• Vapor Pressure: 28.5mmHg at 25°C
• Refractive Index: 1.327
• Boiling Point: 106.3°Cat760mmHg
• Flash Point: 18.1°C
• PSA: 17.07000
• Density: 1.407g/cm³
• LogP: 1.01690
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 113.9683987
• Heavy Atom Count: 6
• Complexity: 64.6

Purity/Quality:

98%min ^*data from raw suppliers

CHLOROFLUOROACETYL FLUORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34-36/37/38
• Safety Statements: 23-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(=O)F)(F)Cl

Technology Process of 2-Chloro-2-fluoroacetyl fluoride

There total 5 articles about 2-Chloro-2-fluoroacetyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.5%

ethoxyflurane (310-71-4) → 1-fluoroethane (353-36-6) + chloroethane (75-00-3) + chlorofluoroacetyl fluoride (359-34-2) + chlorofluoroacetyl chloride (359-32-0)

Guidance literature:

With aluminium trichloride; for 1.58333h;

DOI:10.1016/S0022-1139(00)82333-7

Reference yield: 45.4%

ethoxyflurane (310-71-4) → 1-fluoroethane (353-36-6) + chlorofluoroacetyl fluoride (359-34-2)

Guidance literature:

With boron trifluoride diethyl etherate; for 16.75h; Heating; var. reag.: AlCl₃;

DOI:10.1016/S0022-1139(00)82333-7

Reference yield:

aluminium trichloride (7446-70-0) + 2-chloro-1,1,2-trifluoroethyl methyl ether (425-87-6) → methylene chloride (74-87-3) + Methyl fluoride (593-53-3) + chlorofluoroacetyl fluoride (359-34-2)

Guidance literature:

DOI:10.1021/ja01634a073 DOI:10.1021/ja01123a048

upstream raw materials:

ethoxyflurane

benzyl 2-chloro-1,1,2-trifluoroethyl ether

aluminium trichloride

2-chloro-1,1,2-trifluoroethyl methyl ether

Downstream raw materials:

2-chloro-2-fluoro-N-phenylacetamide

ethyl chlorofluoroacetate

Refernces

• 1、 Hudlicky, Milos. "REACTION OF ALKYL 2-CHLORO-1,1,2-TRIFLUOROETHYL ETHERS WITH LEWIS ACIDS". . p. 349 - 354. Retrieved 2007/10/02.