(R)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate

Base Information Edit

Chemical Name:(R)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate
CAS No.:32345-59-8
Molecular Formula:C9H9 Cl O3
Molecular Weight:200.622
Hs Code.:29181990
European Community (EC) Number:608-730-7
DSSTox Substance ID:DTXSID90472833
Nikkaji Number:J2.474.011K
Wikidata:Q72489384
Mol file:32345-59-8.mol

Synonyms:32345-59-8;(R)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate;C9H9ClO3;Methyl 2-Chloro-D-mandelate;METHYL (2R)-2-(2-CHLOROPHENYL)-2-HYDROXYACETATE;methyl 2-(2-chlorophenyl)-(R)-2-hydroxyacetate;methyl (r)-o-chloromandelate;MFCD02259751;(r)-2-chloromandelic acid methyl ester;SCHEMBL22939;(R)-methyl o-chloromandelate;(R)-Methyl 2-Chloromandelate;DTXSID90472833;ZMPGBVQQIQSQED-MRVPVSSYSA-N;AKOS015917173;2-Chloro-D-mandelic Acid Methyl Ester;2-CHLORO-MANDELICACIDMETHYLESTER;AS-17871;CS-0150950;M2382;methyl(R)-2-hydroxy-2(2-chlorophenyl)acetate;(R)-Methyl2-(2-chlorophenyl)-2-hydroxyacetate;Methyl (R)-2'-Chloro-alpha-hydroxyphenylacetate;Methyl-(R)-2-hydroxy-2-(2-chlorophenyl)acetate;A855061;(R)-2'-Chloro-alpha-hydroxyphenylacetic Acid Methyl Ester

Suppliers and Price of (R)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-Methyl2-Chloromandelate
5g
$ 370.00

TCI Chemical
Methyl 2-Chloro-D-mandelate >98.0%(GC)
25g
$ 400.00

TCI Chemical
Methyl 2-Chloro-D-mandelate >98.0%(GC)
5g
$ 80.00

Crysdot
(R)-Methyl2-(2-chlorophenyl)-2-hydroxyacetate 97%
25g
$ 295.00

Crysdot
(R)-Methyl2-(2-chlorophenyl)-2-hydroxyacetate 97%
5g
$ 145.00

Ambeed
(R)-Methyl2-(2-chlorophenyl)-2-hydroxyacetate 98%
100g
$ 956.00

Ambeed
(R)-Methyl2-(2-chlorophenyl)-2-hydroxyacetate 98%
25g
$ 300.00

Ambeed
(R)-Methyl2-(2-chlorophenyl)-2-hydroxyacetate 98%
1g
$ 21.00

Ambeed
(R)-Methyl2-(2-chlorophenyl)-2-hydroxyacetate 98%
250mg
$ 10.00

Ambeed
(R)-Methyl2-(2-chlorophenyl)-2-hydroxyacetate 98%
5g
$ 76.00

Total 23 raw suppliers

Chemical Property of (R)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate Edit

Chemical Property:

Vapor Pressure:0.001mmHg at 25°C
Melting Point:34 °C
Refractive Index:1.551
Boiling Point:297.663°C at 760 mmHg
PKA:11.82±0.20(Predicted)
Flash Point:133.822°C
PSA：46.53000
Density:1.316g/cm³
LogP:1.54640
Storage Temp.:Sealed in dry,Store in freezer, under -20°C
Solubility.:Chloroform, Dichloromethane, Methanol
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:200.0240218
Heavy Atom Count:13
Complexity:184

Purity/Quality:

99.0%, ^*data from raw suppliers

(R)-Methyl2-Chloromandelate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C(C1=CC=CC=C1Cl)O
Isomeric SMILES:COC(=O)[C@@H](C1=CC=CC=C1Cl)O
Uses (R)-Methyl 2-Chloromandelate is an intermediate in the synthesis of Clopidogrel Carboxylic Acid [Methyl (R)-o-chloromandelate] Ester (C587320), which is an impurity of Clopidogrel (C587250), an antithrombotic agent.

Technology Process of (R)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate

There total 16 articles about (R)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.52%

: 67-56-1
methanol

: 10421-85-9,52923-23-6,52950-19-3,52950-18-2
(R)-2-chloromandelic acid

: 32345-59-8
methyl (R)-2-chloromandelate

Guidance literature:: With sulfuric acid; Reflux;

Reference yield: 92.0%

: 264882-00-0
methyl 2-(2-chlorophenyl)-2-diazoacetate

: 32345-59-8
methyl (R)-2-chloromandelate

Guidance literature:: With iron(II) chloride tetrahydrate; C₃₅H₃₀N₂O₂; sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate; water; In chloroform; at 40 ℃; for 2h; optical yield given as %ee; Inert atmosphere;
DOI:10.1038/nchem.651

Reference yield: 89.0%

: 34966-49-9
methyl 2-chlorobenzoylformate

: 32345-59-8
methyl (R)-2-chloromandelate

Guidance literature:: With D-glucose; NADP; E_. coli BL₂₁(DE₃) cells harboring pESCR and pABGD; In phosphate buffer; at 20 ℃; for 24h;
DOI:10.1039/b703463f