Methyl cyclopentylacetate

Base Information

• Chemical Name: Methyl cyclopentylacetate
• CAS No.: 2723-38-8
• Molecular Formula: C8H14 O2
• Molecular Weight: 142.198
• Hs Code.: 2916209090
• DSSTox Substance ID: DTXSID90500903
• Nikkaji Number: J45.102I
• Wikidata: Q63408881
• Mol file: 2723-38-8.mol

Synonyms:Methylcyclopentaneacetate; Methyl cyclopentylacetate

Chemical Property of Methyl cyclopentylacetate

Chemical Property:

• Boiling Point: 178-179 °C(Press: 100 Torr)
• PSA: 26.30000
• Density: 0.972
• LogP: 1.73970
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 142.099379685
• Heavy Atom Count: 10
• Complexity: 114

Purity/Quality:

99% ^*data from raw suppliers

Cyclopentyl-acetic acid methyl ester 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)CC1CCCC1
• Uses: Methyl cyclopentylacetate is used as a reactant in the diastereoselective preparation of monocyclic and spiro β- or γ-lactams via cobalt-catalyzed intramolecular and intermolecular dehydrogenative amination of unactivated sp3 carbons.

Technology Process of Methyl cyclopentylacetate

There total 8 articles about Methyl cyclopentylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + 2-cyclopentylacetic acid (1123-00-8) → cyclopentylacetic acid methyl ester (2723-38-8)

Guidance literature:

With chloro-trimethyl-silane; at 20 ℃;

Reference yield:

Cyclopentylideneacetic acid methyl ester (40203-73-4) → cyclopentylacetic acid methyl ester (2723-38-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 24h; under 2068.6 Torr;

Reference yield:

cyclopentanone (120-92-3) → cyclopentylacetic acid methyl ester (2723-38-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / 20 h / 125 °C

2: H₂ / 10percent Pd/C / methanol / 24 h / 2068.6 Torr

With hydrogen; palladium on activated charcoal; In methanol;

upstream raw materials:

diazomethane

2-cyclopentylacetic acid

Cyclopentane

methyl diazoacetate

Downstream raw materials:

2-cyclopentyl-ethanol

perfluoro(2-methylcyclopentane)

perfluorocyclohexane

perfluoro-2-propyl-oxolane

Refernces

• 1、 Monjas, Leticia,Swier, Lotteke J. Y. M.,Setyawati, Inda,Slotboom, Dirk J.,Hirsch, Anna K. H.. "Dynamic Combinatorial Chemistry to Identify Binders of ThiT, an S-Component of the Energy-Coupling Factor Transporter for Thiamine". supporting information. p. 1693 - 1696. Retrieved 2017/10/27.
• 2、 -. "Gamma amino butyric and acid analogs". . . Retrieved 2008/06/13.