Technology Process of ethyl 5-(4-methoxybenzoyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate
There total 3 articles about ethyl 5-(4-methoxybenzoyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-methoxybenzoic acid;
With
triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate;
In
N,N-dimethyl-formamide;
for 0.25h;
ethyl 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 5h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: thiophenol; caesium carbonate / acetonitrile / 1 h / 20 °C
2.1: triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h
2.2: 5 h / 20 °C
With
caesium carbonate; thiophenol; triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate;
In
N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: benzene / 1 h / 140 °C / Microwave irradiation
1.2: 0.5 h / 140 °C / Microwave irradiation
2.1: thiophenol; caesium carbonate / acetonitrile / 1 h / 20 °C
3.1: triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h
3.2: 5 h / 20 °C
With
caesium carbonate; thiophenol; triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate;
In
N,N-dimethyl-formamide; acetonitrile; benzene;