METHYL 4-BROMO-L-PHENYLALANINATE HYDROCHLORIDE

Base Information

• Chemical Name: METHYL 4-BROMO-L-PHENYLALANINATE HYDROCHLORIDE
• CAS No.: 99359-32-7
• Molecular Formula: C₁₀H₁₂BrNO₂*(x)ClH
• Molecular Weight: 294.57
• Hs Code.: 2922499990
• Mol file: 99359-32-7.mol

Synonyms:Alanine,3-(p-bromophenyl)-, methyl ester, hydrochloride, L- (6CI); L-Phenylalanine,4-bromo-, methyl ester, hydrochloride (9CI); L-4-Bromophenylalanine methylester hydrochloride

Chemical Property of METHYL 4-BROMO-L-PHENYLALANINATE HYDROCHLORIDE

Chemical Property:

• PSA: 52.32000
• LogP: 2.99420
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

Methyl4-bromo-L-phenylalaninatehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 4-bromo-L-phenylalaninate, HCl

Technology Process of METHYL 4-BROMO-L-PHENYLALANINATE HYDROCHLORIDE

There total 6 articles about METHYL 4-BROMO-L-PHENYLALANINATE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + H-p-BrPhe-OH (24250-84-8) → (S)-2-amino-3-(4-bromophenyl)propionic acid methyl ester hydrochloride (99359-32-7)

Guidance literature:

With thionyl chloride; at 0 ℃; for 2h; Inert atmosphere; Reflux;

DOI:10.1016/j.bmcl.2021.127781

Reference yield: 46.0%

→ (R)-2-amino-3-(4-bromophenyl)propionic acid methyl ester hydrochloride (459133-43-8,99359-32-7)

Guidance literature:

With thionyl chloride; for 2h; Reflux;

Reference yield:

methanol (67-56-1) + p-bromo-DL-phenylalanine (14091-15-7) → H-Phe(4-Br)-OMe hydrochloride (444726-88-9,99359-32-7)

Guidance literature:

With hydrogenchloride; Heating / reflux;

upstream raw materials:

methanol

H-p-BrPhe-OH

4-bromo-N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-phenylalanine

p-bromo-DL-phenylalanine

Downstream raw materials:

C₂₂H₃₂BrN₃O₅S

C₂₀H₂₅N₅O₄

C₁₄H₁₅N₅O₂*C₂HF₃O₂

methyl (±)-3-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate

Refernces

• 1、 Yen, Andy,Pham, Anh Hoang,Larin, Egor M.,Lautens, Mark. "Rhodium-Catalyzed Enantioselective Synthesis of Oxazinones via an Asymmetric Ring Opening-Lactonization Cascade of Oxabicyclic Alkenes". supporting information. p. 7549 - 7553. Retrieved 2019/10/02.
• 2、 -. "TETRAZINE-CONTAINING COMPOUNDS AND SYNTHETIC METHODS THEREOF". Paragraph 0239; 0240. . Retrieved 2016/08/29.