1-(3-Bromopropyl)-2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane

Base Information

• Chemical Name: 1-(3-Bromopropyl)-2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane
• CAS No.: 95091-93-3
• Molecular Formula: C₉H₂₂BrNSi₂
• Molecular Weight: 280.355
• Hs Code.: 2901100000
• European Community (EC) Number: 628-267-4
• DSSTox Substance ID: DTXSID50401629
• Nikkaji Number: J666.938G
• Mol file: 95091-93-3.mol

Synonyms:95091-93-3;1-(3-Bromopropyl)-2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane;1-(3-bromopropyl)-2,2,5,5-tetramethyl-1,2,5-azadisilolidine;SCHEMBL347713;DTXSID50401629;BKBUBAVZGMRPAK-UHFFFAOYSA-N;MFCD00274342;1-Aza-2,5-disilacyclopentane, 1-(3-bromopropyl)-2,2,5,5-tetramethyl-;AKOS015913126;1-(3-bromopropyl)-2,2,5,5-tetramethyl-aza-2,5-disilacyclopentane;1-(3-Bromopropyl)-2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane, 97%

Chemical Property of 1-(3-Bromopropyl)-2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane

Chemical Property:

• Vapor Pressure: 0.0171mmHg at 25°C
• Refractive Index: n20/D 1.484(lit.)
• Boiling Point: 254.6°Cat760mmHg
• PKA: 13.41±0.20(Predicted)
• Flash Point: 107.8°C
• PSA: 3.24000
• Density: 1.12g/cm³
• LogP: 3.43510
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 279.04742
• Heavy Atom Count: 13
• Complexity: 167

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(3-Bromopropyl)-2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane 97% ^*data from reagent suppliers

Safty Information:

• Statements: 10
• Safety Statements: 16

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si]1(CC[Si](N1CCCBr)(C)C)C
• Uses: 1-(3-Bromopropyl)-2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane may be used for the synthesis of PFS-b-PZLys [PFS = Polyferrocenylsilane, PZLys = Poly(epsilon-benzyloxycarbonyl-L-lysine)] block copolymers.

Technology Process of 1-(3-Bromopropyl)-2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane

There total 2 articles about 1-(3-Bromopropyl)-2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-bis-(chlorodimethylsilyl)ethane (13528-93-3) + 3-bromopropylamine hydrochloride (5003-71-4) → 1-(3-bromopropyl)-2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane (95091-93-3)

Guidance literature:

3-bromopropylamine hydrochloride; With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h;

1,2-bis-(chlorodimethylsilyl)ethane; In dichloromethane; at 0 - 20 ℃; for 1.66667h;

DOI:10.1021/jacs.1c11528

Reference yield:

→ 1-(3-bromopropyl)-2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane (95091-93-3)

Guidance literature:

With triethylamine; In toluene; at 80 ℃; for 63h; Inert atmosphere;

Reference yield:

benzonitrile (100-47-0) + 1-(3-bromopropyl)-2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane (95091-93-3) → 2-phenyl-1-pyrroline (700-91-4)

Guidance literature:

With iodine; magnesium; Yield given. Multistep reaction; 1.) Et₂O, reflux, 1 h, 2.) THF, room temperature, 15 h;

DOI:10.1080/00397919608004614

upstream raw materials:

1,2-bis-(chlorodimethylsilyl)ethane

3-bromopropylamine hydrochloride

Downstream raw materials:

2-phenyl-1-pyrroline

5-(p-tolyl)-3,4-dihydro-2H-pyrrole

Refernces

• 1、 -. "METHOD FOR PRODUCING POLYALKYLENE GLYCOL DERIVATIVE HAVING AMINO GROUP AT END". Paragraph 0182-0188. . Retrieved 2016/07/05.