[2-(4-AMINO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: [2-(4-AMINO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER
• CAS No.: 94838-59-2
• Molecular Formula: C13H20 N2 O2
• Molecular Weight: 236.314
• Hs Code.: 2924299090
• Mol file: 94838-59-2.mol

Synonyms:Carbamicacid, [2-(4-aminophenyl)ethyl]-, 1,1-dimethylethyl ester (9CI);N-tert-Butoxycarbonyl-2-(4-aminophenyl)ethylamine;N-tert-Butoxycarbonyl-4-aminophenethylamine; [2-(4-Aminophenyl)ethyl]carbamicacid tert-butyl ester; tert-Butyl (2-(4-Aminophenyl)ethyl)carbamate; tert-Butyl4-aminophenethylcarbamate

Chemical Property of [2-(4-AMINO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER

Chemical Property:

• Boiling Point: 396.8±25.0 °C(Predicted)
• PKA: 12.81±0.46(Predicted)
• PSA: 64.35000
• Density: 1.077±0.06 g/cm3(Predicted)
• LogP: 3.30810
• Storage Temp.: 2-8°C(protect from light)
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98% min ^*data from raw suppliers

N-Boc-4-aminophenethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-[2-(Boc-amino)ethyl]aniline is used as a intermediate for chemical research.

Technology Process of [2-(4-AMINO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER

There total 17 articles about [2-(4-AMINO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(tert-butoxy)-N-[2-(4-nitrophenyl)-ethyl]-carboxamide (144226-16-4) → tert-butyl 4-aminophenethylcarbamate (94838-59-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol;

Reference yield: 99.0%

p-Aminophenethylamine (13472-00-9) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 4-aminophenethylcarbamate (94838-59-2)

Guidance literature:

With Thiamine hydrochloride; In neat (no solvent); at 20 ℃; for 0.05h;

DOI:10.1080/00397911.2021.1994998

Reference yield: 98.0%

→ tert-butyl 4-aminophenethylcarbamate (94838-59-2)

Guidance literature:

upstream raw materials:

(tert-butoxy)-N-[2-(4-nitrophenyl)-ethyl]-carboxamide

p-Aminophenethylamine

di-tert-butyl dicarbonate

tert-butyldicarbonate

Downstream raw materials:

4--N-<(tert-butyloxy)carbonyl>phenethylamine

3-{2-[4-(2-tert-butoxycarbonylamino-ethyl)-phenylcarbamoyl]-vinyl}-4,6-dichloro-1H-indole-2-carboxylic acid ethyl ester

tert-butyl 2-[4-(4H-1,2,4-triazol-4-yl)phenyl]ethyl-carbamate

[2-(4-acetylamino-3-chloro-phenyl)-ethyl]-carbamic acid tert-butyl ester

Refernces

• 1、 Ingale, Ajit P.,Garad, Dnyaneshwar N.,Ukale, Dattatraya,Thorat, Nitin M.,Shinde, Sandeep V.. "Thiamine hydrochloride as a recyclable organocatalyst for the efficient and chemoselective N-tert-butyloxycarbonylation of amines". supporting information. p. 3791 - 3804. Retrieved 2021/11/04.
• 2、 -. "Cannabinoid receptor light-operated ligand and preparation method and application thereof". Paragraph 0066; 0073-0078. . Retrieved 2021/01/24.