2-HYDROXY-CYCLOPENTANECARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 2-HYDROXY-CYCLOPENTANECARBOXYLIC ACID METHYL ESTER
• CAS No.: 933-92-6
• Molecular Formula: C₇H₁₂O₃
• Molecular Weight: 144.17
• Hs Code.: 2918199090
• Mol file: 933-92-6.mol

Synonyms:Cyclopentanecarboxylicacid, 2-hydroxy-, methyl ester, cis- (8CI)

Chemical Property of 2-HYDROXY-CYCLOPENTANECARBOXYLIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0.0395mmHg at 25°C
• Refractive Index: 1.489
• Boiling Point: 212℃
• Flash Point: 85℃
• PSA: 46.53000
• Density: 1.169
• LogP: 0.32040
• Storage Temp.: Room temperature.

Purity/Quality:

99% ^*data from raw suppliers

2-HYDROXY-CYCLOPENTANECARBOXYLICACIDMETHYLESTER 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-HYDROXY-CYCLOPENTANECARBOXYLIC ACID METHYL ESTER

There total 6 articles about 2-HYDROXY-CYCLOPENTANECARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-oxocyclopentane-1-carboxylate (10472-24-9,265317-94-0) → (+/-)-cis-2-hydroxy-cyclopentanecarboxylic acid methyl ester (933-92-6,933-93-7,53229-94-0,53229-95-1,90085-05-5,122331-02-6,122332-63-2,124150-22-7,124150-23-8) + cyclopentanone (120-92-3)

Guidance literature:

With triethylammonium phosphinate; tris(triphenylphosphine)ruthenium(II) chloride; In methanol; at 40 ℃; for 3h; Yield given. Yields of byproduct given;

DOI:10.1016/0040-4039(96)01476-1

Reference yield:

Cyclopentene oxide (285-67-6) + acetic acid (64-19-7,77671-22-8) → cis-Cyclopentanol-2-carbonsaeuremethylester (933-92-6,933-93-7,53229-94-0,53229-95-1,90085-05-5,122331-02-6,122332-63-2,124150-22-7,124150-23-8)

Guidance literature:

With aluminum oxide; In diethyl ether;

DOI:10.1021/ja00467a014

Reference yield:

methyl 2-oxocyclopentane-1-carboxylate (10472-24-9,265317-94-0) → (+/-)-cis-2-hydroxy-cyclopentanecarboxylic acid methyl ester (933-92-6,933-93-7,53229-94-0,53229-95-1,90085-05-5,122331-02-6,122332-63-2,124150-22-7,124150-23-8) + cis-Cyclopentanol-2-carbonsaeuremethylester (933-92-6,933-93-7,53229-94-0,53229-95-1,90085-05-5,122331-02-6,122332-63-2,124150-22-7,124150-23-8)

Guidance literature:

With hydrogen; nickel; In methanol; at 50 ℃; under 750.06 Torr;

DOI:10.1002/hlca.19900730312

upstream raw materials:

methyl 2-oxocyclopentane-1-carboxylate

diazomethane

Cyclopentene oxide

acetic acid

Refernces

• 1、 Khai, Bui The,Arcelli, Antonio. "Stereo- and chemoselective transfer hydrogenation of carbonyl groups with RuCl2(PPh3)3 and BINAP-Ru as catalysts and et3NH+H2PO2-·1,5H 2O as a hydrogen donor". . p. 6599 - 6602. Retrieved 2007/10/03.