2-AMINOMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HYDROCHLORIDE

Base Information

• Chemical Name: 2-AMINOMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HYDROCHLORIDE
• CAS No.: 887626-82-6
• Molecular Formula: C9H18 N2 O2
• Molecular Weight: 186.254
• Hs Code.: 2933998090
• Mol file: 887626-82-6.mol

Synonyms:2-AMINOMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HYDROCHLORIDE

Chemical Property of 2-AMINOMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HYDROCHLORIDE

Chemical Property:

• Boiling Point: 260.6±13.0 °C(Predicted)
• PKA: 9.91±0.29(Predicted)
• PSA: 55.56000
• Density: 1.070±0.06 g/cm3(Predicted)
• LogP: 2.39470
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

98%min ^*data from raw suppliers

(R)-2-Aminomethyl-1-Boc-azetidine 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINOMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HYDROCHLORIDE

There total 4 articles about 2-AMINOMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-tert-butyl 2-(azidomethyl)azetidine-1-carboxylate (1005756-63-7) → (R)-tert-butyl 2-(aminomethyl)azetidine-1-carboxylate (887626-82-6,939760-37-9)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 1h; under 2327.23 Torr;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (R)-tert-butyl 2-(aminomethyl)azetidine-1-carboxylate (887626-82-6,939760-37-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 1,4-dioxane; water / 1 h / 0 - 20 °C

2.1: lithium borohydride; chloro-trimethyl-silane / tetrahydrofuran / 3.5 h / 0 - 20 °C

3.1: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 0.17 h / 0 °C

3.2: 6 h / 65 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 2327.23 Torr

With lithium borohydride; chloro-trimethyl-silane; hydrogen; methanesulfonyl chloride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water;

Reference yield:

(R)-N-(tert-butoxycarbonyl)azetidine-2-carboxylic acid (228857-58-7) → (R)-tert-butyl 2-(aminomethyl)azetidine-1-carboxylate (887626-82-6,939760-37-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium borohydride; chloro-trimethyl-silane / tetrahydrofuran / 3.5 h / 0 - 20 °C

2.1: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 0.17 h / 0 °C

2.2: 6 h / 65 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 2327.23 Torr

With lithium borohydride; chloro-trimethyl-silane; hydrogen; methanesulfonyl chloride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol;

upstream raw materials:

(R)-tert-butyl 2-(azidomethyl)azetidine-1-carboxylate

di-tert-butyl dicarbonate

(R)-N-(tert-butoxycarbonyl)azetidine-2-carboxylic acid

(R)-1-t-butyloxycarbonyl-2-azetidinemethanol

Refernces