7-(4-(3-(1-(6-aminohexyl)-1H-1,2,3-triazol-4-yl)phenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide

Base Information

• Chemical Name: 7-(4-(3-(1-(6-aminohexyl)-1H-1,2,3-triazol-4-yl)phenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide
• CAS No.: 1449289-03-5
• Molecular Formula: C₃₀H₄₀N₈O₄
• Molecular Weight: 576.699
• Mol file: 1449289-03-5.mol

Synonyms:7-(4-(3-(1-(6-aminohexyl)-1H-1,2,3-triazol-4-yl)phenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide

Chemical Property of 7-(4-(3-(1-(6-aminohexyl)-1H-1,2,3-triazol-4-yl)phenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 7-(4-(3-(1-(6-aminohexyl)-1H-1,2,3-triazol-4-yl)phenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide

There total 1 articles about 7-(4-(3-(1-(6-aminohexyl)-1H-1,2,3-triazol-4-yl)phenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

CUDC-101 (1012054-59-9) + 6-azido-hexylamine (349553-73-7) → 7-(4-(3-(1-(6-aminohexyl)-1H-1,2,3-triazol-4-yl)phenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (1449289-03-5)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; for 24h;

DOI:10.1021/ml400191z

Reference yield: 73.0%

7-(4-(3-(1-(6-aminohexyl)-1H-1,2,3-triazol-4-yl)phenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (1449289-03-5) → 2,2',2''-(10-(2-(6-(4-(3-(6-(7-(hydroxyamino)-7-oxoheptyloxy)-7-methoxyquinazolin-4-ylamino)phenyl)-1H-1,2,3-triazol-1-yl)hexylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid (1449289-00-2)

Guidance literature:

With triethylamine; In dimethyl sulfoxide; at 20 ℃;

DOI:10.1021/ml400191z

upstream raw materials:

CUDC-101

6-azido-hexylamine

Downstream raw materials:

2,2',2''-(10-(2-(6-(4-(3-(6-(7-(hydroxyamino)-7-oxoheptyloxy)-7-methoxyquinazolin-4-ylamino)phenyl)-1H-1,2,3-triazol-1-yl)hexylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

Refernces