1-(2-fluorophenyl)naphthalene

Base Information

• Chemical Name: 1-(2-fluorophenyl)naphthalene
• CAS No.: 1246661-49-3
• Molecular Formula: C₁₆H₁₁F
• Molecular Weight: 222.262
• Mol file: 1246661-49-3.mol

Synonyms:1-(2-fluorophenyl)naphthalene

Chemical Property of 1-(2-fluorophenyl)naphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-fluorophenyl)naphthalene

There total 2 articles about 1-(2-fluorophenyl)naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-bromo-1-chlorobenzene (694-80-4) + 1-Bromonaphthalene (90-11-9) → 1-(2-fluorophenyl)naphthalene (1246661-49-3)

Guidance literature:

1-Bromonaphthalene; With magnesium; lithium chloride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

2-bromo-1-chlorobenzene; With magnesium; In tetrahydrofuran; at 20 - 60 ℃; Inert atmosphere;

With 1-fluoro-2,4,6-trimethylpyridin-1-ium tetrafluoroborate; In tetrahydrofuran; n-heptane; at 0 ℃; for 2h; Inert atmosphere;

DOI:10.1002/asia.201000288

Reference yield: 52.0%

o-fluorobromobenzene (1072-85-1) + 1-Naphthylboronic acid (13922-41-3) → 1-(2-fluorophenyl)naphthalene (1246661-49-3)

Guidance literature:

With C₆₄H₆₈Cl₄N₆O₂Pd₂; potassium hydroxide; In 1,4-dioxane; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.3184/174751918X15293145282582

Reference yield: 93.0%

1-(2-fluorophenyl)naphthalene (1246661-49-3) → fluoranthene (206-44-0)

Guidance literature:

With dimethyldimesitylsilane; In chlorobenzene; at 110 ℃; for 8h; Inert atmosphere;

DOI:10.1126/science.1202432

upstream raw materials:

2-bromo-1-chlorobenzene

1-Bromonaphthalene

o-fluorobromobenzene

1-Naphthylboronic acid

Downstream raw materials:

fluoranthene

Refernces

• 1、 Anbarasan, Pazhamalai,Neumann, Helfried,Beller, Matthias. "A new and practical grignard-coupling-fluorination sequence: Synthesis of 2-aryl fluoroarenes". supporting information; experimental part. p. 1775 - 1778. Retrieved 2011/03/19.