3-{2-[3-(fluorophenyl)-3-(trimethyl silyloxy)-propyl]-3-(4-fluoro phenyl amino)-3-(4-trimethyl silyloxy phenyl)-1-oxo-propyl}-4-(S)-phenyl oxazolidin-2-one

Base Information

• Chemical Name: 3-{2-[3-(fluorophenyl)-3-(trimethyl silyloxy)-propyl]-3-(4-fluoro phenyl amino)-3-(4-trimethyl silyloxy phenyl)-1-oxo-propyl}-4-(S)-phenyl oxazolidin-2-one
• CAS No.: 858126-22-4
• Molecular Formula: C₃₉H₄₆F₂N₂O₅Si₂
• Molecular Weight: 716.972
• Mol file: 858126-22-4.mol

Synonyms:3-{2-[3-(fluorophenyl)-3-(trimethyl silyloxy)-propyl]-3-(4-fluoro phenyl amino)-3-(4-trimethyl silyloxy phenyl)-1-oxo-propyl}-4-(S)-phenyl oxazolidin-2-one

Chemical Property of 3-{2-[3-(fluorophenyl)-3-(trimethyl silyloxy)-propyl]-3-(4-fluoro phenyl amino)-3-(4-trimethyl silyloxy phenyl)-1-oxo-propyl}-4-(S)-phenyl oxazolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{2-[3-(fluorophenyl)-3-(trimethyl silyloxy)-propyl]-3-(4-fluoro phenyl amino)-3-(4-trimethyl silyloxy phenyl)-1-oxo-propyl}-4-(S)-phenyl oxazolidin-2-one

There total 1 articles about 3-{2-[3-(fluorophenyl)-3-(trimethyl silyloxy)-propyl]-3-(4-fluoro phenyl amino)-3-(4-trimethyl silyloxy phenyl)-1-oxo-propyl}-4-(S)-phenyl oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.3%

chloro-trimethyl-silane (75-77-4) + 3-[5-(4-fluorophenyl)-1,5-dioxopentyl]-4-phenyl-2-oxazolidinone (1076200-08-2,404874-93-7) + N-(4-hydroxybenzylidene)-4-fluorobenzenamine (3382-63-6,942485-62-3) → 3-{2-[3-(fluorophenyl)-3-(trimethyl silyloxy)-propyl]-3-(4-fluoro phenyl amino)-3-(4-trimethyl silyloxy phenyl)-1-oxo-propyl}-4-(S)-phenyl oxazolidin-2-one (858126-22-4)

Guidance literature:

3-[5-(4-fluorophenyl)-1,5-dioxopentyl]-4-phenyl-2-oxazolidinone; With dimethylsulfide borane complex; ascorbic acid; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In dichloromethane; at -10 - 8 ℃; for 7.25h; Inert atmosphere; Large scale;

With dihydrogen peroxide; In methanol; dichloromethane; at -5 - 20 ℃; for 0.5h; Inert atmosphere; Large scale;

chloro-trimethyl-silane; N-(4-hydroxybenzylidene)-4-fluorobenzenamine; Further stages; Large scale;

Reference yield:

3-{2-[3-(fluorophenyl)-3-(trimethyl silyloxy)-propyl]-3-(4-fluoro phenyl amino)-3-(4-trimethyl silyloxy phenyl)-1-oxo-propyl}-4-(S)-phenyl oxazolidin-2-one (858126-22-4) → ezetemibe (163222-33-1,1478664-18-4,1593543-00-0,1593543-07-7,1478664-02-6)

Guidance literature:

3-{2-[3-(fluorophenyl)-3-(trimethyl silyloxy)-propyl]-3-(4-fluoro phenyl amino)-3-(4-trimethyl silyloxy phenyl)-1-oxo-propyl}-4-(S)-phenyl oxazolidin-2-one; With tetrabutyl ammonium fluoride; N,N-bis(trimethylsilyl)acetamide; In toluene; at 25 - 35 ℃; for 0.5 - 1h;

With sulfuric acid; In methanol; water; at 25 - 35 ℃; for 0.5 - 1h;

upstream raw materials:

chloro-trimethyl-silane

3-[5-(4-fluorophenyl)-1,5-dioxopentyl]-4-phenyl-2-oxazolidinone

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

Downstream raw materials:

ezetemibe

Refernces