FMOC-LEU-OSU

Base Information

• Chemical Name: FMOC-LEU-OSU
• CAS No.: 76542-83-1
• Molecular Formula: C25H26 N2 O6
• Molecular Weight: 450.491
• Mol file: 76542-83-1.mol

Synonyms:Carbamicacid, [1-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]-3-methylbutyl]-, 9H-fluoren-9-ylmethylester, (S)- (9CI)

Chemical Property of FMOC-LEU-OSU

Chemical Property:

• Refractive Index: 1.62
• PSA: 102.01000
• Density: 1.33g/cm³
• LogP: 3.87580
• Storage Temp.: Store at 0°C

Purity/Quality:

98.5% ^*data from raw suppliers

FMOC-LEU-OSU ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-LEU-OSU

There total 1 articles about FMOC-LEU-OSU which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + Fmoc-Leu-OH (35661-60-0) → Fmoc-Leu-OSu (76542-83-1)

Guidance literature:

With dicyclohexyl-carbodiimide;

DOI:10.1016/j.bmcl.2007.01.066

Reference yield: 81.0%

Fmoc-Leu-OSu (76542-83-1) + methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → Fmoc-Leu-Phe-OMe (827018-96-2)

Guidance literature:

With sodium hydrogencarbonate; In acetone; at 40 ℃; for 0.0833333h;

Reference yield: 75.0%

Fmoc-Leu-OSu (76542-83-1) + L-valine benzyl ester p-toluenesulfonate salt (16652-76-9) → Fmoc-Leu-Val-OBzl

Guidance literature:

With sodium hydrogencarbonate; In acetone; at 40 ℃; for 0.166667h;

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

Fmoc-Leu-OH

Downstream raw materials:

(S)-(9H-fluoren-9-yl)methyl (1-hydroxy-4-methylpentan-2-yl)carbamate

Fmoc-Leu-Phe-OMe

Refernces

• 1、 Yang, Jinhua,Wang, Changliu,Yao, Chaochao,Chen, Chunqiu,Hu, Yafang,He, Guifeng,Zhao, Junfeng. "Site-Specific Incorporation of Multiple Thioamide Substitutions into a Peptide Backbone via Solid Phase Peptide Synthesis". . p. 1484 - 1494. Retrieved 2020/01/02.
• 2、 Jadhav, Sandip V.,Bandyopadhyay, Anupam,Benke, Sushil N.,Mali, Sachitanand M.,Gopi, Hosahudya N.. "A facile synthesis and crystallographic analysis of N-protected β-amino alcohols and short peptaibols". supporting information; experimental part. p. 4182 - 4187. Retrieved 2011/06/28.