Technology Process of N-benzyl-2-(2-methyl-1H-indol-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amine
There total 7 articles about N-benzyl-2-(2-methyl-1H-indol-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
ethyl acetate;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 16.25 h / 0 - 20 °C
2: triethylamine / dichloromethane / 16 h / 0 - 20 °C
3: acetonitrile / 12 h / 0 - 20 °C
4: potassium tert-butylate; tris-(dibenzylideneacetone)dipalladium(0); XPhos / 1,4-dioxane / 3 h / 0 - 80 °C / Inert atmosphere
5: hydrogenchloride / ethyl acetate / 1 h / 20 °C
With
hydrogenchloride; tris-(dibenzylideneacetone)dipalladium(0); carbonochloridic acid 1-chloro-ethyl ester; potassium tert-butylate; triethylamine; XPhos;
In
1,4-dioxane; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: sodium methylate / methanol / 96 h / 0 - 60 °C / Inert atmosphere
2: trichlorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 0 - 130 °C
3: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 16.25 h / 0 - 20 °C
4: triethylamine / dichloromethane / 16 h / 0 - 20 °C
5: acetonitrile / 12 h / 0 - 20 °C
6: potassium tert-butylate; tris-(dibenzylideneacetone)dipalladium(0); XPhos / 1,4-dioxane / 3 h / 0 - 80 °C / Inert atmosphere
7: hydrogenchloride / ethyl acetate / 1 h / 20 °C
With
hydrogenchloride; tris-(dibenzylideneacetone)dipalladium(0); carbonochloridic acid 1-chloro-ethyl ester; potassium tert-butylate; sodium methylate; triethylamine; N-ethyl-N,N-diisopropylamine; XPhos; trichlorophosphate;
In
1,4-dioxane; methanol; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;