1-(Aminomethyl)cyclopropanol

Base Information

• Chemical Name: 1-(Aminomethyl)cyclopropanol
• CAS No.: 74592-33-9
• Molecular Formula: C₄H₉NO
• Molecular Weight: 87.1216
• Hs Code.: 2922199090
• European Community (EC) Number: 806-368-6
• DSSTox Substance ID: DTXSID00504275
• Wikidata: Q82358648
• Mol file: 74592-33-9.mol

Synonyms:1-(aminomethyl)cyclopropanol;74592-33-9;1-(Aminomethyl)-cyclopropanol;1-(AMINOMETHYL)CYCLOPROPAN-1-OL;MFCD04972522;Cyclopropanol, 1-(aminomethyl)-;DTXSID00504275;JXJORHGRCCODBV-UHFFFAOYSA-N;1-AMINOMETHYL-CYCLOPROPANOL;AKOS006283277;AB21151;CS-W005471;GS-3903;AC-13210;AM804312;SY102292;1-(aminomethyl)-cyclopropanol, AldrichCPR;FT-0743826;A22608;EN300-134628

Chemical Property of 1-(Aminomethyl)cyclopropanol

Chemical Property:

• Vapor Pressure: 1.22mmHg at 25°C
• Refractive Index: 1.555
• Boiling Point: 153.7°C at 760 mmHg
• PKA: 12.99±0.20(Predicted)
• Flash Point: 46.7°C
• PSA: 46.25000
• Density: 1.186g/cm³
• LogP: 0.17030
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: -1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 87.068413911
• Heavy Atom Count: 6
• Complexity: 58.6

Purity/Quality:

99% ^*data from raw suppliers

1-(Aminomethyl)cyclopropanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1(CN)O
• Uses: 1-(Aminomethyl)cyclopropanol is a useful chemical reactant used in the preparation of 5-lipoxygenase activating protein (FLAP) inhibitors for the treatment of inflammatory diseases.

Technology Process of 1-(Aminomethyl)cyclopropanol

There total 2 articles about 1-(Aminomethyl)cyclopropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-((diphenylmethylamino)methyl)cyclopropan-1-ol (428855-17-8) → 1-(aminomethyl)cyclopropan-1-ol (74592-33-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol; at 50 ℃; for 12h; under 2585.81 Torr;

Reference yield:

1-((2,5-dimethyl-1H-pyrrol-1-yl)methyl)cyclopropanol → 1-(aminomethyl)cyclopropan-1-ol (74592-33-9)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydroxide; In ethanol; water; at 0 - 82 ℃; for 5h;

upstream raw materials:

1-((diphenylmethylamino)methyl)cyclopropan-1-ol

Refernces

• 1、 -. "Synthesis method of 1-aminomethyl-1-cyclopropanol". Paragraph 0044-0052. . Retrieved 2020/08/09.