Technology Process of (2S,6R)-3-Oxo-6-<(phenylmethoxy)carbonyl>-2-piperazineacetic acid methyl ester
There total 6 articles about (2S,6R)-3-Oxo-6-<(phenylmethoxy)carbonyl>-2-piperazineacetic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1) (CF3SO2)2, 2) 2,6-lutidine / 1) CH2Cl2, -78 deg C, 5 min 2) CH2Cl2, -78 deg C to r.t., 18h
2: 85 percent / Ph3P / tetrahydrofuran; H2O / 72 h / Ambient temperature
With
2,6-dimethylpyridine; (CF3SO2)2; triphenylphosphine;
In
tetrahydrofuran; water;
DOI:10.1016/S0040-4039(00)60843-2
- Guidance literature:
-
Multi-step reaction with 5 steps
1: dioxane; H2O
2: HN3, diisopropyl azodicarboxylate, Ph3P / 18 h / -78 deg C to r.t.
3: TFA / CH2Cl2 / 0.5 h / 0 deg C to r.t.
4: 1) (CF3SO2)2, 2) 2,6-lutidine / 1) CH2Cl2, -78 deg C, 5 min 2) CH2Cl2, -78 deg C to r.t., 18h
5: 85 percent / Ph3P / tetrahydrofuran; H2O / 72 h / Ambient temperature
With
2,6-dimethylpyridine; tris-(2-chloro-ethyl)-amine; di-isopropyl azodicarboxylate; (CF3SO2)2; triphenylphosphine; trifluoroacetic acid;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1016/S0040-4039(00)60843-2
