2-(1-methyl-1H-pyrazol-5-yl)acetic acid

Base Information

• Chemical Name: 2-(1-methyl-1H-pyrazol-5-yl)acetic acid
• CAS No.: 1071814-44-2
• Molecular Formula: C₆H₈N₂O₂
• Molecular Weight: 140.142
• Mol file: 1071814-44-2.mol

Synonyms:2-(1-methyl-1H-pyrazol-5-yl)acetic acid

Chemical Property of 2-(1-methyl-1H-pyrazol-5-yl)acetic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-(1-Methyl-1H-pyrazol-5-yl)acetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1-methyl-1H-pyrazol-5-yl)acetic acid

There total 8 articles about 2-(1-methyl-1H-pyrazol-5-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(1H-pyrazol-3-yl)acetate (82668-50-6) + methyl iodide (74-88-4) → 2-(1-methyl-1H-pyrazol-5-yl)acetic acid (1071814-44-2) + 2-(1-methyl-1H-pyrazol-3-yl)acetic acid (1177318-00-1)

Guidance literature:

ethyl 2-(1H-pyrazol-3-yl)acetate; methyl iodide; With caesium carbonate; In N,N-dimethyl-formamide; for 2h; Cooling with ice;

With lithium hydroxide monohydrate; In ethanol; water; at 20 ℃; for 0.5h;

Reference yield:

2-(1-methyl-1H-pyrazol-5-yl)acetonitrile (1071814-43-1) → 2-(1-methyl-1H-pyrazol-5-yl)acetic acid (1071814-44-2)

Guidance literature:

With hydrogenchloride; water; In 1,4-dioxane; for 20h; Heating / reflux;

Reference yield:

1-methyl-1H-pyrazole-5-carbaldehyde (27258-33-9) → 2-(1-methyl-1H-pyrazol-5-yl)acetic acid (1071814-44-2)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium tetrahydroborate / ethanol / 0.5 h / 5 °C

2: thionyl chloride / dichloromethane / 3 h / 20 °C

3: dimethyl sulfoxide / 3 h / 50 °C

4: hydrogenchloride; water / 1,4-dioxane / 20 h / Heating / reflux

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; water; In 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide;

upstream raw materials:

2-(1-methyl-1H-pyrazol-5-yl)acetonitrile

1-methyl-1H-pyrazole-5-carbaldehyde

5-(chloromethyl)-1-methyl-1H-pyrazole

(1-methyl-1H-pyrazol-5-yl)methanol

Downstream raw materials:

N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-2-(1-methyl-1H-pyrazol-5-yl)acetamide

2-(4-chloro-1-methyl-1H-pyrazol-5-yl)-N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}acetamide

N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-2-(4-fluoro-1-methyl-1H-pyrazol-5-yl)acetamide

2-(4-bromo-1-methyl-1H-pyrazol-5-yl)-N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}acetamide

Refernces

• 1、 -. "PYRAZOLE DERIVATIVES AS P2X7 MODULATORS". Page/Page column 30. . Retrieved 2008/12/08.