4-iodo-2-neopentylphenol

Base Information

• Chemical Name: 4-iodo-2-neopentylphenol
• CAS No.: 868266-21-1
• Molecular Formula: C₁₁H₁₅IO
• Molecular Weight: 290.144
• Mol file: 868266-21-1.mol

Synonyms:4-iodo-2-neopentylphenol

Chemical Property of 4-iodo-2-neopentylphenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-iodo-2-neopentylphenol

There total 2 articles about 4-iodo-2-neopentylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

2-neopentylphenol (16670-59-0) → 4-iodo-2-neopentylphenol (868266-21-1)

Guidance literature:

With sodium hydroxide; sodium hypochlorite; sodium iodide; In methanol; at 0 - 1 ℃; for 1.16667h;

Reference yield:

t-butylboronic acid (86253-12-5) + C14H13IN2O3S → 4-iodo-2-neopentylphenol (868266-21-1)

Guidance literature:

With caesium carbonate; In 1,4-dioxane; at 110 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.0c00471

Reference yield: 78.0%

N-(tert-butoxycarbonylmethyl)-N-(2-hydroxyethyl)methyl-amine (791643-07-7) + 4-iodo-2-neopentylphenol (868266-21-1) → ({2-[2-(2,2-dimethylpropyl)-4-iodophenoxy]ethyl}-methylamino)-acetic acid tert-butyl ester

Guidance literature:

With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In toluene; at 90 ℃; for 4h;

upstream raw materials:

2-neopentylphenol

t-butylboronic acid

Refernces

• 1、 -. "2-ARYLOXYETHYL GLYCINE DERIVATIVES AND THEIR USE AS GLYCINE TRANSPORT INHIBITORS". Page/Page column 111. . Retrieved 2010/02/14.