FMOC-LEU-ONP

Base Information

• Chemical Name: FMOC-LEU-ONP
• CAS No.: 71989-25-8
• Molecular Formula: C27H26 N2 O6
• Molecular Weight: 474.51
• Mol file: 71989-25-8.mol

Synonyms:FMOC-LEUCINE-ONP;FMOC-LEU-ONP;FMOC-L-LEUCINE 4-NITROPHENYL ESTER;N-ALPHA-FMOC-L-LEUCINE P-NITROPHENYL ESTER

Chemical Property of FMOC-LEU-ONP

Chemical Property:

• Refractive Index: 1.604
• PSA: 110.45000
• LogP: 6.36770
• Storage Temp.: -15°C

Purity/Quality:

98%Min ^*data from raw suppliers

Fmoc-L-leucine 4-nitrophenyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-LEU-ONP

There total 1 articles about FMOC-LEU-ONP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + Fmoc-Leu-OH (35661-60-0) → Fmoc-Leu-ONp (71989-25-8)

Guidance literature:

With dicyclohexyl-carbodiimide; In ethyl acetate; at 0 ℃;

DOI:10.1021/jo01289a016

Reference yield: 91.0%

Fmoc-Leu-ONp (71989-25-8) + Boc-Phe-Ala-NHNHZ (83704-76-1) → Fmoc-Leu-Phe-Ala-NHNHZ (83704-79-4)

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In trifluoroacetic acid;

DOI:10.1021/ja00388a114

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + Fmoc-Leu-ONp (71989-25-8) → C28H27ClN2O6

Guidance literature:

With thionyl chloride; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.10.149

upstream raw materials:

4-nitro-phenol

Fmoc-Leu-OH

Downstream raw materials:

Fmoc-Leu-Phe-Ala-NHNHZ

Refernces