4S-[2,6-difluoro-4-(2-methyl-1-butyl)phenyl]ethynyl-4'-pentylbiphenyl

Base Information

• Chemical Name: 4S-[2,6-difluoro-4-(2-methyl-1-butyl)phenyl]ethynyl-4'-pentylbiphenyl
• CAS No.: 1443253-86-8
• Molecular Formula: C₃₀H₃₂F₂
• Molecular Weight: 430.581
• Mol file: 1443253-86-8.mol

Synonyms:4S-[2,6-difluoro-4-(2-methyl-1-butyl)phenyl]ethynyl-4'-pentylbiphenyl

Chemical Property of 4S-[2,6-difluoro-4-(2-methyl-1-butyl)phenyl]ethynyl-4'-pentylbiphenyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4S-[2,6-difluoro-4-(2-methyl-1-butyl)phenyl]ethynyl-4'-pentylbiphenyl

There total 9 articles about 4S-[2,6-difluoro-4-(2-methyl-1-butyl)phenyl]ethynyl-4'-pentylbiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-iodoo-4'-n-pentylbiphenyl (69971-79-5) → 4S-[2,6-difluoro-4-(2-methyl-1-butyl)phenyl]ethynyl-4'-pentylbiphenyl (1443253-86-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 5 h

1.2: 110 °C

2.1: 3 h

1.1: |Sonogashira Cross-Coupling / 2.1: |Sonogashira Cross-Coupling;

DOI:10.1016/j.tetlet.2013.04.118

Reference yield:

(S)-1,3-difluoro-2-iodo-5-(2-methyl-1-butyl)benzene (1443253-81-3) + 4-ethynyl-4′-pentyl-1,1′-biphenyl (80563-43-5) → 4S-[2,6-difluoro-4-(2-methyl-1-butyl)phenyl]ethynyl-4'-pentylbiphenyl (1443253-86-8)

Guidance literature:

for 3h;

DOI:10.1016/j.tetlet.2013.04.118

Reference yield:

(S)-2-methylbutyl bromide (534-00-9) → 4S-[2,6-difluoro-4-(2-methyl-1-butyl)phenyl]ethynyl-4'-pentylbiphenyl (1443253-86-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: magnesium / tetrahydrofuran / 1 h / Inert atmosphere; Reflux

1.2: 48 h / Reflux; Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / -70 °C

2.2: -70 °C

3.1: 3 h

With n-butyllithium; magnesium; In tetrahydrofuran; 3.1: |Sonogashira Cross-Coupling;

DOI:10.1016/j.tetlet.2013.04.118

upstream raw materials:

(S)-2-methylbutyl bromide

1-pentyl-4-phenylbenzene

1-Bromopentane

3,5-difluorobromobenzene

Refernces

• 1、 Herman, Jakub,Kula, Przemys?aw. "The synthesis of chiral fluorinated 4-alkyl-4′-[(4-alkylphenyl) ethynyl]biphenyls". . p. 3621 - 3623. Retrieved 2013/07/05.