4,6-DICHLORO-NICOTINAMIDE

Base Information

• Chemical Name: 4,6-DICHLORO-NICOTINAMIDE
• CAS No.: 70593-57-6
• Molecular Formula: C6H4Cl2N2O
• Molecular Weight: 191.017
• Hs Code.: 2933399090
• Mol file: 70593-57-6.mol

Synonyms:Nicotinamide,4,6-dichloro- (7CI);4,6-Dichloro-3-pyridinecarboxamide;4,6-Dichloronicotinamide;

Chemical Property of 4,6-DICHLORO-NICOTINAMIDE

Chemical Property:

• Vapor Pressure: 0.000965mmHg at 25°C
• Melting Point: 153-155°C
• Refractive Index: 1.603
• Boiling Point: 302.9 °C at 760 mmHg
• PKA: 13.91±0.50(Predicted)
• Flash Point: 137 °C
• PSA: 55.98000
• Density: 1.524g/cm³
• LogP: 2.18760
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

4,6-Dichloronicotinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4,6-Dichloronicotinamide

Technology Process of 4,6-DICHLORO-NICOTINAMIDE

There total 8 articles about 4,6-DICHLORO-NICOTINAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4,6-dichloro-nicotinic acid (73027-79-9) → 4,6-dichloro-nicotinamide (70593-57-6)

Guidance literature:

4,6-dichloro-nicotinic acid; With oxalyl dichloride; N,N-dimethyl-formamide; at 20 ℃; for 3h;

With ammonium hydroxide; In dichloromethane; at 25 ℃; for 1.5h;

Reference yield:

4,6-dihydroxy-nicotinic acid (5466-62-6) → 4,6-dichloro-nicotinamide (70593-57-6)

Guidance literature:

4,6-dihydroxy-nicotinic acid; With trichlorophosphate; at 100 ℃; for 4h;

With ammonium hydroxide; In water;

Reference yield:

4,6-dichloropyridine-3-carbonyl chloride (107836-75-9) → 4,6-dichloro-nicotinamide (70593-57-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 0.25h;

upstream raw materials:

4,6-dichloro-nicotinic acid

4,6-dihydroxy-nicotinic acid

benzotriazol-1-ol

ethyl 4,6-dichloronicotinate

Downstream raw materials:

6-(4-fluoro-3-(pyrrolidine-1-carboxamido)phenylamino)-4-(pyridin-3-ylmethylamino)nicotinamide

4-(1-phenylcyclopropylamino)-6-(4-(4-propionylpiperazin-1-yl)phenylamino)nicotinamide

4-(3-(1H-imidazol-1-yl)benzylamino)-6-(4-(dimethylcarbamoyl)phenylamino)nicotinamide

4-(1-phenylcyclopropylamino)-6-(3-(piperazin-1-yl)phenylamino)nicotinamide

Refernces

• 1、 Bhide, Rajeev S.,Keon, Alec,Weigelt, Carolyn,Sack, John S.,Schmidt, Robert J.,Lin, Shuqun,Xiao, Hai-Yun,Spergel, Steven H.,Kempson, James,Pitts, William J.,Carman, Julie,Poss, Michael A.. "Discovery and structure-based design of 4,6-diaminonicotinamides as potent and selective IRAK4 inhibitors". . p. 4908 - 4913. Retrieved 2017/09/27.
• 2、 -. "NICOTINAMIDES AS JAK KINASE MODULATORS". Page/Page column 55. . Retrieved 2012/05/07.