BOC-LYS(FMOC)-OME

Base Information

• Chemical Name: BOC-LYS(FMOC)-OME
• CAS No.: 133628-28-1
• Molecular Formula: C₂₇H₃₄N₂O₆
• Molecular Weight: 482.577
• Mol file: 133628-28-1.mol

Synonyms:BOC-LYSINE(FMOC)-OME;BOC-LYS(FMOC)-OME;BOC-N-EPSILON-FMOC-L-LYSINE METHYL ESTER;N-T-BUTOXYCARBONYL-N-9-FLUORENYLMETHOXYCARBONYL-L-LYSINE METHYL ESTER

Chemical Property of BOC-LYS(FMOC)-OME

Chemical Property:

• Boiling Point: 653.7±55.0 °C(Predicted)
• PKA: 11.16±0.46(Predicted)
• PSA: 102.96000
• Density: 1.169±0.06 g/cm3(Predicted)
• LogP: 5.54350
• Storage Temp.: 2-8°C
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98.5% ^*data from raw suppliers

Boc-Lys(Fmoc)-OMe 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is employed as a intermediate for pharmaceutical.

Technology Process of BOC-LYS(FMOC)-OME

There total 2 articles about BOC-LYS(FMOC)-OME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + Boc-Lys(Fmoc)-OH (84624-27-1) → N-α-Boc-N-ε-Fmoc-L-lysine methyl ester (133628-28-1)

Guidance literature:

In diethyl ether; for 0.166667h;

DOI:10.1021/jm00111a029

Reference yield:

Boc-Lys(Fmoc)-OH (84624-27-1) + methyl iodide (74-88-4) → N-α-Boc-N-ε-Fmoc-L-lysine methyl ester (133628-28-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.6b00801

Reference yield: 67.0%

N-α-Boc-N-ε-Fmoc-L-lysine methyl ester (133628-28-1) → Boc-Lys(Fmoc)-OH (84624-27-1)

Guidance literature:

With bis(tri-n-butyltin)oxide; In toluene; at 100 ℃; for 24h;

DOI:10.1016/S0040-4020(01)90225-X

upstream raw materials:

diazomethane

Boc-Lys(Fmoc)-OH

methyl iodide

Downstream raw materials:

Boc-Lys(Fmoc)-OH

Refernces

• 1、 Stuckey, Jacob I.,Simpson, Catherine,Norris-Drouin, Jacqueline L.,Cholensky, Stephanie H.,Lee, Junghyun,Pasca, Ryan,Cheng, Nancy,Dickson, Bradley M.,Pearce, Kenneth H.,Frye, Stephen V.,James, Lindsey I.. "Structure-Activity Relationships and Kinetic Studies of Peptidic Antagonists of CBX Chromodomains". . p. 8913 - 8923. Retrieved 2016.