N-ME-LEU-OBZL P-TOSYLATE

Base Information

• Chemical Name: N-ME-LEU-OBZL P-TOSYLATE
• CAS No.: 42807-66-9
• Molecular Formula: C21H29NO5S
• Molecular Weight: 407.52400
• Mol file: 42807-66-9.mol

Synonyms:N-ME-LEUCINE-OBZL P-TOSYLATE;H-N-Me-Leu-OBzl.TosOH;N-Me-Leu-OBzl;H-ME-LEU-OBZL TOS-OH;N-METHYL-L-LEUCINE BENZYL ESTER 4-TOLUENESULFONATE SALT;N-Methyl-L-leucine phenylmethyl ester 4-methylbenzenesulfonate;N-ME-LEU-OBZL TOSOH;

Chemical Property of N-ME-LEU-OBZL P-TOSYLATE

Chemical Property:

• PSA: 101.08000
• LogP: 5.07730
• Storage Temp.: Store at RT.

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Me-leu-obzl p-tosylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-ME-LEU-OBZL P-TOSYLATE

There total 2 articles about N-ME-LEU-OBZL P-TOSYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-t-butoxycarbonyl-N-methyl-L-leucine (53363-89-6) + toluene-4-sulfonic acid (104-15-4) + benzyl alcohol (100-51-6,185532-71-2) → N-Me-Leu-OBzl p-toluenesulfonic acid salt (1208162-98-4,42807-66-9)

Guidance literature:

In toluene; for 0.00833333h; microwave irradiation;

DOI:10.1081/SCC-200063953

Reference yield:

N-tert-butoxycarbonyl-N-methyl-D-leucine (89536-84-5) + toluene-4-sulfonic acid (104-15-4) + benzyl alcohol (100-51-6,185532-71-2) → H-N-Me-D-Leu-OBzl p-toluenesulfonic acid salt (1208162-98-4,42807-66-9)

Guidance literature:

In toluene; for 0.00833333h; microwave irradiation;

DOI:10.1081/SCC-200063953

Reference yield:

N-Me-Leu-OBzl p-toluenesulfonic acid salt (1208162-98-4,42807-66-9) → C34H41N3O5

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; 1-hydroxy-7-aza-benzotriazole / N,N-dimethyl-formamide / 0.08 h / Inert atmosphere

1.2: 17 h / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1 h / Inert atmosphere

With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.7b00723

upstream raw materials:

N-t-butoxycarbonyl-N-methyl-L-leucine

toluene-4-sulfonic acid

benzyl alcohol

N-tert-butoxycarbonyl-N-methyl-D-leucine

Refernces