Ac-Cys(Trt)-ONSu

Base Information

• Chemical Name: Ac-Cys(Trt)-ONSu
• CAS No.: 73609-53-7
• Molecular Formula: C₂₈H₂₆N₂O₅S
• Molecular Weight: 502.591
• Mol file: 73609-53-7.mol

Synonyms:Ac-Cys(Trt)-ONSu

Chemical Property of Ac-Cys(Trt)-ONSu

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ac-Cys(Trt)-ONSu

There total 5 articles about Ac-Cys(Trt)-ONSu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + N-acetyl-S-trityl-L-cysteine (27486-87-9) → N-methylmorpholine hydrochloride (3651-67-0) + Ac-Cys(Trt)-ONSu (73609-53-7)

Guidance literature:

With 4-methyl-morpholine; isobutyl chloroformate; In ethyl acetate; at -15 ℃; for 2.5h;

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + N-acetyl-S-trityl-L-cysteine (27486-87-9) → Ac-Cys(Trt)-ONSu (73609-53-7)

Guidance literature:

With 4-methyl-morpholine; isobutyl chloroformate; Yield given. Multistep reaction; 1.) EtOAc, -15 deg C, 30 s;

DOI:10.1021/jm00180a027

Reference yield:

N-acetyl-S-trityl-L-cysteine (27486-87-9) → Ac-Cys(Trt)-ONSu (73609-53-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine / ethyl acetate / 0.33 h / -15 °C

2: ethyl acetate / 0.25 h / -15 °C

With 4-methyl-morpholine; In ethyl acetate;

DOI:10.1016/S0960-894X(01)00171-8

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

N-acetyl-S-trityl-L-cysteine

S-trityl-L-cysteine

Downstream raw materials:

N-(N-acetyl-S-trityl-L-cysteinyl)-S-acetylcysteamine

N-(N-acetyl-S-trityl-L-cysteinyl)-S-benzoylcysteamine

N-(N-acetyl-S-trityl-L-cysteinyl)-S-pivaloylcysteamine

N-(N-acetyl-S-trityl-L-cysteinyl)-S-isobutyrylcysteamine

Refernces

• 1、 Smietana, Michael,Clayette, Pascal,Mialocq, Patricia,Vasseur, Jean-Jacques,Oiry, Joel. "Synthesis of new N-isobutyryl-l-cysteine/MEA conjugates: Evaluation of their free radical-scavenging activities and anti-HIV properties in human macrophages". . p. 133 - 140. Retrieved 2008/09/20.
• 2、 -. "Novel antioxidants, preparation processes and their uses". Page 12. . Retrieved 2010/02/08.