Technology Process of 1-((R)-hex-1-yn-3-yloxy)-4-methylbenzene
There total 2 articles about 1-((R)-hex-1-yn-3-yloxy)-4-methylbenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
for 18h;
DOI:10.1021/ol070110b
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 74 percent / (S)-5,5-Ph2-2-methyl-3,4-propano-1,3,2-oxazoborolidine; BH3*Me2S / toluene; tetrahydrofuran / -40 - -20 °C
2: 10 percent / PPh3; diisopropyl azodicarboxylate / tetrahydrofuran / 18 h / 20 °C
With
di-isopropyl azodicarboxylate; dimethylsulfide borane complex; triphenylphosphine; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole;
In
tetrahydrofuran; toluene;
2: Mitsunobu reaction;
DOI:10.1021/ol070110b
- Guidance literature:
-
With
hydrogen;
Lindlar's catalyst;
In
methanol;
at 20 ℃;
for 16h;
under 760 Torr;
DOI:10.1021/ol070110b
