Rohm & Haas Paraloid B-67

Base Information

• Chemical Name: Rohm & Haas Paraloid B-67
• CAS No.: 53801-42-6
• Molecular Formula: C₁₄H₁₈O₂
• Molecular Weight: 218.296
• Mol file: 53801-42-6.mol

Synonyms:Rohm & Haas Paraloid B-67

Chemical Property of Rohm & Haas Paraloid B-67

Chemical Property:

• Refractive Index: 1.422
• Boiling Point: 160°Cat760mmHg
• Flash Point: 50.6°C
• Density: 0.894g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Rohm & Haas Paraloid B-67

There total 4 articles about Rohm & Haas Paraloid B-67 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-methylcinnamic acid (1866-39-3,940-61-4) + 2-methyl-propan-1-ol (78-83-1) → (E)-isobutyl 3-(p-tolyl)acrylate (53801-42-6)

Guidance literature:

With sulfuric acid; for 5h; Reflux;

DOI:10.1021/ol1021756

Reference yield: 38.0%

Isobutyl iodide (513-38-2) + (Z)-2,3-diphenylprop-2-enoic acid (91-47-4) → isobutyl Z-2,3-diphenylpropenoate (53801-42-6)

Guidance literature:

(Z)-2,3-diphenylprop-2-enoic acid; With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 0.5h;

Isobutyl iodide; In dimethyl sulfoxide; at 20 ℃; for 1h;

DOI:10.3390/90400256

Reference yield:

α-phenyl-α'-isobutoxycarbonylthio ylide + benzyl bromide (100-39-0) → isobutyl E-2,3-diphenylpropenoate + isobutyl Z-2,3-diphenylpropenoate (53801-42-6)

Guidance literature:

With trifuran-2-yl-phosphane; palladium diacetate; triethylamine; lithium tert-butoxide; In toluene; at 80 ℃; for 24h; Overall yield = 75 percent; Overall yield = 21.1 mg; stereoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1039/d0cc06236g

upstream raw materials:

2-methyl-propan-1-ol

trans-p-methylcinnamic acid

4-methylcinnamic acid

Isobutyl iodide

Downstream raw materials:

iso-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-p-tolylpropanoate

Refernces

• 1、 Park, Jin Kyoon,Lackey, Hershel H.,Rexford, Matthew D.,Kovnir, Kirill,Shatruk, Michael,McQuade, D. Tyler. "A chiral 6-membered n -heterocyclic carbene copper(I) complex that induces high stereoselectivity". supporting information; experimental part. p. 5008 - 5011. Retrieved 2010/12/25.