3-[3-(TRIFLUOROMETHYL)PHENYL]-2-PROPENOYLHLORIDE

Base Information

• Chemical Name: 3-[3-(TRIFLUOROMETHYL)PHENYL]-2-PROPENOYLHLORIDE
• CAS No.: 60689-14-7
• Molecular Formula: C10H6ClF3O
• Molecular Weight: 234.605
• Hs Code.: 2916399090
• Mol file: 60689-14-7.mol

Synonyms:3-[3-(TRIFLUOROMETHYL)PHENYL]-2-PROPENOYLCHLORIDE;3-[3-(TRIFLUOROMETHYL)PHENYL]-2-PROPENOYLHLORIDE

Chemical Property of 3-[3-(TRIFLUOROMETHYL)PHENYL]-2-PROPENOYLHLORIDE

Chemical Property:

• Boiling Point: 232.9±0.0 °C(Predicted)
• PSA: 17.07000
• Density: 1.360±0.06 g/cm3(Predicted)
• LogP: 3.48400

Purity/Quality:

99%min ^*data from raw suppliers

3-(TRIFLUOROMETHYL)CINNAMOYL CHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-[3-(TRIFLUOROMETHYL)PHENYL]-2-PROPENOYLHLORIDE

There total 6 articles about 3-[3-(TRIFLUOROMETHYL)PHENYL]-2-PROPENOYLHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-(trifluoromethyl)cinnamic acid (779-89-5,67801-07-4) → trans-3-(trifluoromethyl)cinnamoyl chloride (60689-14-7,64379-91-5)

Guidance literature:

With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; Reflux; Inert atmosphere;

DOI:10.1016/j.bmc.2017.08.047

Reference yield:

3-(trifluoromethyl)cinnamic acid (779-89-5,67801-07-4) → 3-(3-(trifluoromethyl)phenyl)acryloyl chloride (60689-14-7,64379-91-5)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In chloroform; for 3.5h; Heating;

DOI:10.1016/S0968-0896(97)00093-X

Reference yield:

3-Trifluoromethylbenzaldehyde (454-89-7) → trans-3-(trifluoromethyl)cinnamoyl chloride (60689-14-7,64379-91-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; piperidine / 90 °C

2: oxalyl dichloride / dichloromethane / 20 °C

With piperidine; pyridine; oxalyl dichloride; In dichloromethane;

DOI:10.2174/1570180811666140812231519

upstream raw materials:

3-(trifluoromethyl)cinnamic acid

3-Trifluoromethylbenzaldehyde

3-(trifluoromethyl)cinnamic acid

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

Refernces

• 1、 Li, Peng-Xiao,Li, Yan-Mo,Liu, Guo-Yun,Liu, Ren-Min,Mu, Wen-Wen,Sun, Ai-Ling,Sun, Ya-Lei,Yang, Jie. "Piperlongumine analogs promote A549 cell apoptosis through enhancing ROS generation". . . Retrieved 2021/06/11.
• 2、 Li, Peng-Xiao,Liu, Guo-Yun,Liu, Ren-Min,Liu, Yue,Mu, Wen-Wen,Sun, Ya-Lei,Yang, Jie. "Design, Synthesis, and Anticancer Activity of Cinnamoylated Barbituric Acid Derivatives". . . Retrieved 2022/01/13.