METHYL ALPHA-BROMOPHENYL ACETATE

Base Information

• Chemical Name: METHYL ALPHA-BROMOPHENYL ACETATE
• CAS No.: 704-65-4
• Molecular Formula: C9H9BrO2
• Molecular Weight: 229.073
• Hs Code.: 2915390090
• Mol file: 704-65-4.mol

Synonyms:2-(Bromomethyl)phenyl acetate;

Chemical Property of METHYL ALPHA-BROMOPHENYL ACETATE

Chemical Property:

• PSA: 26.30000
• LogP: 2.50680
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99% ^*data from raw suppliers

2-(Bromomethyl)phenylAcetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL ALPHA-BROMOPHENYL ACETATE

There total 7 articles about METHYL ALPHA-BROMOPHENYL ACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-Bromosuccinimide (128-08-5) + 2-methylphenyl acetate (533-18-6) → 2-(bromomethyl)phenyl acetate (704-65-4)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); o-methylphenylacetic acid; In cyclohexane; at 80 ℃; for 0.5h;

Reference yield: 87.0%

2-methylphenyl acetate (533-18-6) → 2-(bromomethyl)phenyl acetate (704-65-4)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In benzene; for 6h; Reflux; Inert atmosphere;

DOI:10.1021/ol901437f

Reference yield:

ortho-cresol (95-48-7,77504-84-8) → 2-(bromomethyl)phenyl acetate (704-65-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / 3 h / 130 °C

2: 71 percent / bromine / CCl₄ / Heating; Irradiation

With bromine; In tetrachloromethane;

DOI:10.1016/S0040-4020(01)92357-9

upstream raw materials:

1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione

2-methylphenyl acetate

o-acetoxybenzyl acetate

ortho-cresol

Downstream raw materials:

2-[(tert-butylthio)methyl]phenol

Acetic acid 2-(1,4,7,10,13-pentaoxa-16-aza-cyclooctadec-16-ylmethyl)-phenyl ester

N,N'-ethylenebis[N-(o-hydroxybenzyl)glycine]

N-(2-Hydroxybenzyl)sarcosine methyl ester

Refernces

• 1、 -. "Method for preparing multi-target small-molecule compounds S63845". Paragraph 0017; 0019; 0027. . Retrieved 2018/03/26.
• 2、 -. "NEW HYDROXYESTER DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM". Page/Page column 28-29. . Retrieved 2017/01/09.