P-ACETAMIDOBENZENESULFINIC ACID

Base Information

• Chemical Name: P-ACETAMIDOBENZENESULFINIC ACID
• CAS No.: 710-24-7
• Molecular Formula: C8H9NO3S
• Molecular Weight: 199.23
• Hs Code.: 2930909090
• Mol file: 710-24-7.mol

Synonyms:4-ACETAMIDOBENZENESULPHINIC ACID;P-ACETYLAMINOBENZENESULFINIC ACID;P-ACETYLAMINOPHENYLSULFINIC ACID;P-ACETAMIDOBENZENESULFINIC ACID;P-ACETAMIDOPHENYLSULFINIC ACID;P-ACETAMINO BENZENE SULFINIC ACID;4-acetamidobenzenesulfinic acid

Chemical Property of P-ACETAMIDOBENZENESULFINIC ACID

Chemical Property:

• Melting Point: 152-154 °C (decomp)
• PKA: 0.65±0.11(Predicted)
• PSA: 89.10000
• Density: 1.46±0.1 g/cm3(Predicted)
• LogP: 2.74080
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Methanol

Purity/Quality:

99%, ^*data from raw suppliers

4-ACETAMIDOBENZENESULFINIC ACID ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: P-Acetamidobenzenesulfinic Acid is a component used in the preparation of Cyanine dyes.

Technology Process of P-ACETAMIDOBENZENESULFINIC ACID

There total 11 articles about P-ACETAMIDOBENZENESULFINIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.07%

Acetanilid (103-84-4) → 4-acetamidobenzenesulfinic acid (710-24-7)

Guidance literature:

With hydrogenchloride; aluminium(III) triflate; sulfur dioxide; In ethanol; at 0 ℃; for 50h; under 7600.51 Torr; Pressure; Temperature;

Reference yield: 72.0%

p-acetylaminobenzenesulfonyl chloride (121-60-8) → 4-acetamidobenzenesulfinic acid (710-24-7)

Guidance literature:

With sodium hydrogencarbonate; sodium sulfite; In water; at 70 - 80 ℃; for 1h;

DOI:10.1016/S0223-5234(99)00219-6

Reference yield: 49.0%

o-nitrophenyl N-acetylthiosulfanilate (18522-22-0) + N,N'-diethyl-N,N'-diphenylmethionamide (77505-27-2) → 4-acetamidobenzenesulfinic acid (710-24-7) + (2-Nitro-phenylsulfanyl)-methanedisulfonic acid bis-(ethyl-phenyl-amide)

Guidance literature:

With potassium; Yield given. Multistep reaction; 1) toluene, 2) 70 deg C, 10 h, boiling water bath, 1 h;

upstream raw materials:

p-acetylaminobenzenesulfonyl chloride

4-acetamidobenzenesulfonylhydrazine

o-nitrophenyl N-acetylthiosulfanilate

N,N'-diethyl-N,N'-diphenylmethionamide

Downstream raw materials:

acetic acid-[4-(3-oxo-1,3-diphenyl-propane-1-sulfonyl)-anilide]

bis(4-acetylaminophenyl sulfone)

2,5-bis-(N-acetyl-sulfanilyl)-N,N-dimethyl-p-phenylenediamine

4'-acetamidophenyl-4-acetamidobenzene thiolsulfonate

Refernces

• 1、 -. "Method for preparing 4-acetamidobenzene sulfinic acid". Paragraph 0027; 0029-0051. . Retrieved 2021/07/10.
• 2、 Saab, Nada H.,Donkor, Isaac O.,Rodriguez, Libaniel,Kador, Peter F.,Miller, Duane D.. "Phenylsulfonylnitromethanes as potent irreversible inhibitors of aldose reductase". . p. 745 - 751. Retrieved 2007/10/03.