1-Thiophen-3-yl-propan-2-one

Base Information

• Chemical Name: 1-Thiophen-3-yl-propan-2-one
• CAS No.: 62119-77-1
• Molecular Formula: C7H8OS
• Molecular Weight: 140.20282
• Hs Code.: 2934999090
• Mol file: 62119-77-1.mol

Synonyms:1-Thiophen-3-yl-propan-2-one;3-(2-Ketopropyl)-thiophene

Chemical Property of 1-Thiophen-3-yl-propan-2-one

Chemical Property:

• PSA: 45.31000
• LogP: 1.87960

Purity/Quality:

98%Min ^*data from raw suppliers

1-Thiophen-3-yl-2-oxo-propane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Thiophen-3-yl-propan-2-one

There total 14 articles about 1-Thiophen-3-yl-propan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

thiophen-3-yl-acetic acid (6964-21-2) + acetic anhydride (108-24-7) → 1-(thiophen-3-yl)propan-2-one (62119-77-1)

Guidance literature:

thiophen-3-yl-acetic acid; acetic anhydride; With 1-methyl-1H-imidazole; at 20 ℃; for 4h; Inert atmosphere;

With water; at 0 ℃; for 1h; Inert atmosphere;

Reference yield: 77.0%

1-methyl-1H-imidazole (616-47-7) + thiophen-3-yl-acetic acid (6964-21-2) → 1-(thiophen-3-yl)propan-2-one (62119-77-1)

Guidance literature:

With acetic anhydride; sodium hydroxide; at 20 ℃; for 4h; Inert atmosphere;

Reference yield: 72.0%

tri-n-butyl(thien-3-yl)tin (119405-65-1) + 2-ethoxyallyl diethyl phosphate (112472-96-5) → 1-(thiophen-3-yl)propan-2-one (62119-77-1)

Guidance literature:

bis-triphenylphosphine-palladium(II) chloride; In benzene; react. mixt. washed (aq. KF); extn.of org. layer (ether); dried over MgSO4; product isolated by distn. (reduced pressure); acetonylated by chromy. (silica gel);

DOI:10.1246/bcsj.62.3383

upstream raw materials:

(E)-3-(2-nitroprop-1-en-1-yl)thiophene

Okahara's reagent

tri-n-butyl(thien-3-yl)tin

2-ethoxyallyl diethyl phosphate

Downstream raw materials:

3-(2-amino-1-propyl)thiophene

1-(tert-butoxycarbonyl)-5'-methyl-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-2'-carboxylic acid

methyl-(1-methyl-2-[3]thienyl-ethyl)-amine

Refernces

• 1、 Ledgard, Andrew J.,Martin, Fionna M.,Mutton, Simon P.,Richardson, Jeffery,Walton, Lesley. "An Efficient Palladium-Catalyzed α-Arylation of Acetone below its Boiling Point". . . Retrieved 2020/07/24.
• 2、 -. "COMPOUNDS USEFUL FOR INHIBITING ROR-GAMMA-T". Paragraph 0028; 0029. . Retrieved 2017/03/28.