5-IODO-1,3-DIMETHYLURACIL

Base Information

• Chemical Name: 5-IODO-1,3-DIMETHYLURACIL
• CAS No.: 40738-83-8
• Molecular Formula: C6H7 I N2 O2
• Molecular Weight: 266.038
• Hs Code.: 2933599090
• Mol file: 40738-83-8.mol

Synonyms:1,3-Dimethyl-5-iodouracil;5-Iodo-1,3-dimethyluracil

Chemical Property of 5-IODO-1,3-DIMETHYLURACIL

Chemical Property:

• Vapor Pressure: 0.0116mmHg at 25°C
• Melting Point: 225oC
• Boiling Point: 261.3oC at 760 mmHg
• Flash Point: 111.8oC
• PSA: 44.00000
• Density: 2.04g/cm3
• LogP: -0.31140
• Storage Temp.: Room temperature.
• Sensitive.: Light Sensitive
• Solubility.: DMSO: soluble10mg/mL(lit.)

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Iodo-1,3-dimethylpyrimidine-2,4(1H,3H)-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-42/43-63
• Safety Statements: 22-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 5-Iodo-1,3-dimethyluracil may be used for the synthesis of N-[2-[(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)thio]-4-oxo[1]benzothieno[3,2-d]pyrimidin-3(4H)yl]methanesulfonamide.

Technology Process of 5-IODO-1,3-DIMETHYLURACIL

There total 5 articles about 5-IODO-1,3-DIMETHYLURACIL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

indole (120-72-9) + (1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(3-(trifluoromethyl)phenyl)-λ3-iodanyl trifluoromethanesulfonate → 3-(3-(trifluoromethyl)phenyl)-1H-indole + 5-iodo-1,3-dimethyluracil (40738-83-8)

Guidance literature:

With copper(l) iodide; 2,6-di-tert-butyl-pyridine; In toluene; at 60 ℃; for 24h; Sealed tube; Inert atmosphere;

DOI:10.1021/ja5124754

Reference yield:

indole (120-72-9) + (3,4-dichlorophenyl)(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-λ3-iodanyl trifluoromethanesulfonate → 3-(3,4-dichlorophenyl)-1H-indole + 5-iodo-1,3-dimethyluracil (40738-83-8)

Guidance literature:

With copper(l) iodide; 2,6-di-tert-butyl-pyridine; In toluene; at 60 ℃; for 24h; Sealed tube; Inert atmosphere;

DOI:10.1021/ja5124754

Reference yield:

indole (120-72-9) + (1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(4-fluorophenyl)-λ3-iodanyl trifluoromethanesulfonate → 3-(4-fluorophenyl)-1H-indole (101125-32-0) + 5-iodo-1,3-dimethyluracil (40738-83-8)

Guidance literature:

With copper(l) iodide; 2,6-di-tert-butyl-pyridine; In toluene; at 60 ℃; for 24h; Sealed tube; Inert atmosphere;

DOI:10.1021/ja5124754

upstream raw materials:

indole

5-methoxylindole

Downstream raw materials:

3-(N,N-dimethyl-2',4'-dioxo-1',2',3',4'3,6-diphenyl-6,7-dihydro-4H-[1,2,3]triazolo[5,1-c][1,4]oxazine-tetrahydropyrimidin-5-yl)-7-phenyl-6,7-dihydro-4H-[1,2,3]triazolo[5,1-c][1,4]oxazine

5-[5-(3-benzyloxycarbonyloxy-4-oxo-chromen-2-yl)-thiophen-2-yl-ethynyl]-1,3-N,N-dimethyluracil

Refernces